IMPC phenotypes (gene matching)
C57BL/6N-Bap1tm1c(EUCOMM)Hmgu/WtsiPh
| Status | Available to order |
| EMMA ID | EM:14399 |
| Citation information | RRID:IMSR_EM:14399 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Bap1tm1c(EUCOMM)Hmgu/WtsiPh |
| Alternative name | HEPD0526_2_G01 |
| Strain type | Targeted Mutant Strains : Targeted Conditional |
| Allele/Transgene symbol | Bap1tm1c(EUCOMM)Hmgu |
| Gene/Transgene symbol | Bap1 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Wellcome Trust Sanger Institute |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | This line originates from EUCOMM ES clone HEPD0526_2_G01, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Uveal melanoma / Orphanet_39044
- BAP1-related tumor predisposition syndrome / Orphanet_289539
- Meningioma / Orphanet_2495
- Pleural mesothelioma / Orphanet_50251
- Non-specific syndromic intellectual disability / Orphanet_528084
MGI phenotypes (gene matching)
- increased mammary adenocarcinoma incidence / MGI
- no phenotypic analysis / MGI
- embryonic growth retardation / MGI
- increased squamous cell carcinoma incidence / MGI
- increased incidence of tumors by chemical induction / MGI
- hematopoietic system phenotype / MGI
- increased ovary tumor incidence / MGI
- increased lung carcinoma incidence / MGI
- abnormal DNA methylation / MGI
- increased skin tumor incidence / MGI
- increased mesothelioma incidence / MGI
- increased pancreatic islet cell carcinoma incidence / MGI
- embryonic lethality between implantation and placentation, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- abnormal epigenetic regulation of gene expression / MGI
- increased granulosa cell tumor incidence / MGI
- increased lymphoma incidence / MGI
- increased colon tumor incidence / MGI