B6J.B6N-C9orf72em1.1(GA400)Aisa/H

Status

Only small colony available

EMMA IDEM:14600
Citation informationRRID:IMSR_EM:14600 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6J.B6N-C9orf72em1.1(GA400)Aisa/H
Alternative nameC57BL/6J-C9orf72tm1.1(GA400)Aisa
Strain typeEndonuclease-mediated
Allele/Transgene symbolC9orf72em1.1(GA400)Aisa
Gene/Transgene symbolC9orf72

Information from provider

ProviderAdrian Isaacs
Provider affiliationUCL
Genetic informationKnock-in of 400 codon-optimised GA repeats directly downstream of the mouse C9orf72 ATG start codon. CRISPR technology details: the Cas9 was obtained from IDT and it has not been integrated in the mouse genome.
Phenotypic informationHomozygous:
We have not generated homozygous mice.

Heterozygous:
No clinical signs via observation. No survival or body weight deficit.
Breeding historyES cells used were C57BL/6N, followed by 5 generations of backcrossing to C57BL/6J.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • epithelial hyperplasia / IMPC
  • hyperplasia / IMPC
  • decreased total body fat amount / IMPC
  • enlarged spleen / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • chronic inflammation / IMPC
  • abnormal spleen morphology / IMPC
  • lymphoid hyperplasia / IMPC
  • abnormal vertebral arch morphology / IMPC
  • increased lean body mass / IMPC
  • increased spleen weight / IMPC
  • myeloid hyperplasia / IMPC
  • inflammation / IMPC
  • small testis / IMPC
  • enlarged lymph nodes / IMPC
  • acute inflammation / IMPC

Information on how we integrate external resources can be found here

Order (limited)

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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