C57BL/6NTac-Gdf5^em1(IMPC)H/H

Status	Available to order
EMMA ID	EM:14728
Citation information	RRID:IMSR_EM:14728 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NTac-Gdf5^em1(IMPC)H/H
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Gdf5^em1(IMPC)H
Gene/Transgene symbol	Gdf5

Information from provider

Provider	MRC, Medical Research Council
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Acromesomelic dysplasia, Hunter-Thompson type / Orphanet_968
Brachydactyly type C / Orphanet_93384
Brachydactyly type A1 / Orphanet_93388
Angel-shaped phalango-epiphyseal dysplasia / Orphanet_63442
Fibular aplasia-complex brachydactyly syndrome / Orphanet_2639
Acromesomelic dysplasia, Grebe type / Orphanet_2098
Multiple synostoses syndrome / Orphanet_3237
Proximal symphalangism / Orphanet_3250
Brachydactyly type A2 / Orphanet_93396

IMPC phenotypes (allele matching)

increased bone mineral density / IMPC
decreased leukocyte cell number / IMPC
abnormal forelimb morphology / IMPC
abnormal hindlimb morphology / IMPC
abnormal autopod morphology / IMPC
decreased locomotor activity / IMPC
abnormal gait / IMPC
decreased exploration in new environment / IMPC
limb grasping / IMPC
abnormal digit morphology / IMPC
decreased vertical activity / IMPC
abnormal bone structure / IMPC
decreased lymphocyte cell number / IMPC

IMPC phenotypes (gene matching)

abnormal autopod morphology / IMPC
abnormal gait / IMPC
decreased exploration in new environment / IMPC
abnormal digit morphology / IMPC
decreased grip strength / IMPC
abnormal bone structure / IMPC
increased bone mineral density / IMPC
abnormal forelimb morphology / IMPC
decreased lymphocyte cell number / IMPC
decreased leukocyte cell number / IMPC
abnormal hindlimb morphology / IMPC
decreased locomotor activity / IMPC
decreased vertical activity / IMPC
limb grasping / IMPC

MGI phenotypes (gene matching)

delayed bone ossification / MGI
abnormal long bone epiphysis morphology / MGI
abnormal cartilage morphology / MGI
abnormal cartilage development / MGI
decreased chondrocyte number / MGI
short limbs / MGI
abnormal carpal bone morphology / MGI
abnormal tibia morphology / MGI
abnormal femur morphology / MGI
abnormal autopod morphology / MGI
decreased body weight / MGI
reduced male fertility / MGI
decreased litter size / MGI
abnormal limb morphology / MGI
abnormal digit morphology / MGI
abnormal limb bone morphology / MGI
abnormal fibula morphology / MGI
disproportionate dwarf / MGI
brachyphalangia / MGI
brachydactyly / MGI
short tibia / MGI
short fibula / MGI
brachypodia / MGI
abnormal long bone epiphyseal plate morphology / MGI
abnormal metatarsal bone morphology / MGI
abnormal metacarpal bone morphology / MGI
short femur / MGI
fused joints / MGI
delayed endochondral bone ossification / MGI
abnormal long bone morphology / MGI
short humerus / MGI
short radius / MGI
short ulna / MGI
short metacarpal bones / MGI
short metatarsal bones / MGI
decreased length of long bones / MGI
abnormal tarsal bone morphology / MGI
abnormal phalanx morphology / MGI
abnormal patella morphology / MGI
abnormal limb development / MGI
abnormal digit development / MGI
abnormal articular cartilage morphology / MGI
abnormal endochondral bone ossification / MGI
fused phalanges / MGI
micromelia / MGI
fused carpal bones / MGI
decreased birth weight / MGI
abnormal limb long bone morphology / MGI
joint dislocation / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
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