C57BL/6N-Irgm1em1(IMPC)Wtsi/WtsiCnbc

Status

Available to order

EMMA IDEM:14780
International strain nameC57BL/6N-Irgm1em1(IMPC)Wtsi/WtsiCnbc
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolIrgm1em1(IMPC)Wtsi
Gene/Transgene symbolIrgm1

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivingheterozygous C57BL/6N

Disease and phenotype information

IMPC phenotypes (allele matching)
  • increased circulating LDL cholesterol level / IMPC
  • decreased hematocrit / IMPC
  • increased neutrophil cell number / IMPC
  • increased monocyte cell number / IMPC
  • decreased leukocyte cell number / IMPC
  • decreased mean corpuscular volume / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased hemoglobin content / IMPC
  • decreased erythrocyte cell number / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • thrombocytopenia / IMPC
  • increased lean body mass / IMPC
  • decreased eosinophil cell number / IMPC
  • decreased B cell number / IMPC
  • decreased T cell number / IMPC
  • decreased circulating serum albumin level / IMPC
  • decreased circulating glucose level / IMPC
  • decreased NK T cell number / IMPC
  • decreased NK cell number / IMPC
  • increased CD4-positive, alpha beta T cell number / IMPC
  • decreased CD8-positive, alpha-beta T cell number / IMPC
  • decreased mature B cell number / IMPC
  • decreased gamma-delta T cell number / IMPC
  • decreased total body fat amount / IMPC
  • increased red blood cell distribution width / IMPC
  • decreased circulating fructosamine level / IMPC
  • decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • decreased effector memory CD4-positive, alpha-beta T cell number / IMPC
  • decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • decreased alpha-beta T cell number / IMPC
  • increased KLRG1-positive NK cell number / IMPC
  • decreased KLRG1-positive NK cell number / IMPC

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).