| Status | Available to order |
| EMMA ID | EM:14894 |
| Citation information | RRID:IMSR_EM:14894 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6N.129-Loxtm1Soin/Oulu |
| Alternative name | B6.129-LoxtmSoin/Oulu |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Loxtm1Soin |
| Gene/Transgene symbol | Lox |
| Provider | Joni Mäki |
| Provider affiliation | University of Oulu |
| Genetic information | Lysyl oxidase (Lox) gene was inactivated by deleting its 1st exon in mouse embryonic stem (ES) cells. ES cells carrying the inactivated Lox gene were generated by two-step targeting method comprising homologous recombination followed by cre recombination. The presently submitted strain (EMMA ID EM:14894) is on C57BL/6N background to provide a wider background for this animal model. The same mutation is also carried by the previously submitted EM:07434 EMMA strain, which is on C57BL/6JOlaHsd background. The C57BL/6JOlaHsd substrain differs from other C57BL/6J substrains, as it carries a deletion in the Snca gene that is not present in any other B6 substrain. The Snca mutation may be of importance e.g. for studies on Parkinson’s disease. Most C57BL/6J mice have a deletion in Nnt gene that results in inappropriate glucose homeostasis in B6J male mice. Regarding this gene the C57BL/6JOlaHsd substrain resembles C57BL/6N lines, which do not carry this mutation. |
| Phenotypic information | Homozygous:Perinatal death, cardiovascular defects, pulmonary defects, muscular defects, bone abnormalities, collagen and elastin abnormalities. Heterozygous:Viable. No defects observed. |
| Breeding history | The Lox mouse line is backcrossed to C57BL/6N for hundreds of generations. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | University of Oulu, Oulu, Finland |
Orphanet associated rare diseases, based on orthologous gene matching
