B6N(Cg)-Palmtm1.1Kili/Ieg
| Status | Available to order |
| EMMA ID | EM:14920 |
| International strain name | B6N(Cg)-Palmtm1.1Kili/Ieg |
| Alternative name | Palm-tm1.1Kili (official allele design., MGI:6883582) lab. design.: Palm1c (cond-KO) |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Palmtm1.1Kili, |
| Gene/Transgene symbol | Palm |
Information from provider
| Provider | Manfred Kilimann |
| Provider affiliation | Molecular Neurobiology, MPI for Multidisciplinary Sciences |
| Genetic information | Exon 5 of the mouse paralemmin 1 gene was flanked with loxP sites by homologous recombination. The cre recombinase-mediated deletion of exon 5 will result in a frame-shift. Germline deletion, leading to constitutive knock-out mice (Palmtm1.2Kili allele, EMMA strain EM:14921), has been shown to completely abolish paralemmin 1 protein expression (detection limit, |
| Phenotypic information | Homozygous:No phenotype. The mice carry a conditional, floxed allele.Heterozygous:No phenotype. |
| Breeding history | The mutation was generated in a C57BL/6N ES cell line and mice were subsequently backcrossed to C57BL/6N mice for more than 5 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | homozygous C57BL/6N |
Literature references
- Paralemmin-1 is expressed in lymphatic endothelial cells and modulates cell migration, cell maturation and tumor lymphangiogenesis.;Albrecht Imke, Bieri Raphael, Leu Angela, Granacher Philipp, Hagmann Jörg, Kilimann Manfred W, Christofori Gerhard, ;2013;Angiogenesis;16;795-807; 23709172