IMPC phenotypes (gene matching)
B6N(Cg)-Palmdtm1.1Kili/Ieg
| Status | Available to order |
| EMMA ID | EM:14922 |
| Citation information | RRID:IMSR_EM:14922 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6N(Cg)-Palmdtm1.1Kili/Ieg |
| Alternative name | Palmd-tm1.1Kili (official allele design., MGI:6477925) lab. design.: Palmdc (conditional Palmd-KO) |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Palmdtm1.1Kili |
| Gene/Transgene symbol | Palmd |
Information from provider
| Provider | Manfred Kilimann |
| Provider affiliation | Molecular Neurobiology, MPI for Multidisciplinarc Sciences |
| Genetic information | Exons 4-6 of the mouse Palmd gene are flanked en-bloc by loxP sites in introns 3 and 6, generated by homologous recombination. This provides the option for deleting this DNA interval by cre recombinase, resulting in a frame-shift. Germ-line cre deletion of this allele has been carried out, generating the constitutive Palmdtm1.2Kili knock-out line (EMMA strain EM:14923), which is a proven null mutant with undetectable Palmd protein expression (detection limit of Western blot analysis: |
| Phenotypic information | Homozygous:No phenotype.Heterozygous:No phenotype. |
| Breeding history | Mice were generated in a C57BL/6N ES cell line and subsequently backcrossed to C57BL/6N mice for more than 5 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6N males |
Disease and phenotype information
Literature references
- Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium.;Sáinz-Jaspeado Miguel, Smith Ross O, Plunde Oscar, Pawelzik Sven-Christian, Jin Yi, Nordling Sofia, Ding Yindi, Aspenström Pontus, Hedlund Marie, Bastianello Giulia, Ascione Flora, Li Qingsen, Demir Cansaran Saygili, Fernando Dinesh, Daniel Geoffrey, Franco-Cereceda Anders, Kroon Jeffrey, Foiani Marco, Petrova Tatiana V, Kilimann Manfred W, Bäck Magnus, Claesson-Welsh Lena, ;2021;Circulation;144;1629-1645; 34636652