IMPC phenotypes (gene matching)
C57BL/6NTac-Snap29tm1c(EUCOMM)Wtsi/Orl
| Status | Available to order |
| EMMA ID | EM:14931 |
| Citation information | RRID:IMSR_EM:14931 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NTac-Snap29tm1c(EUCOMM)Wtsi/Orl |
| Alternative name | C57BL/6NTac-Snap29tm1c(EUCOMM)Wtsi/WtsiCnbc |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Snap29tm1c(EUCOMM)Wtsi |
| Gene/Transgene symbol | Snap29 |
Information from provider
| Provider | Cécile FREMOND |
| Provider affiliation | CNRS-TAAM-CDTA-UAR44 |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0065_4_B10. For further details on the construction of this clone see the relevant page at the IMPC portal (https://www.mousephenotype.org/data/alleles/MGI:1914724/tm1a(EUCOMM)Wtsi). Rederived tm1a mice (EMMA strain EM:05226) have been crossed with flp recombinase-deleter mice (EMMA strain EM:05490, C57BL/6NTac-Gt(ROSA)26Sortm2(CAG-flpo,-EYFP)Ics/Ics) to obtain the tm1c allele. |
| Phenotypic information | Homozygous:Homozygous mice have not been generated.Heterozygous:Nothing. |
| Breeding history | Rederived tm1a mice (EMMA strain EM:05226) have been crossed with flp-deleter mice (EMMA strain EM:05490) to obtain the tm1c allele. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6NTac males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- CEDNIK syndrome / Orphanet_66631
MGI phenotypes (gene matching)
- increased bone mineral density / MGI
- scaly skin / MGI
- tight skin / MGI
- hyperkeratosis / MGI
- increased body weight / MGI
- acanthosis / MGI
- increased lean body mass / MGI
- abnormal skin physiology / MGI
- abnormal autophagy / MGI
- abnormal epidermal lamellar body morphology / MGI
- decreased birth body size / MGI
- abnormal skin appearance / MGI
- increased bone mineral content / MGI
- abnormal endoplasmic reticulum physiology / MGI
- increased endoplasmic reticulum stress / MGI