FVB-Tg(Slc12a5*/luc)#Msa/Oulu
| Status | Available to order |
| EMMA ID | EM:14936 |
| Citation information | RRID:IMSR_EM:14936 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | FVB-Tg(Slc12a5*/luc)#Msa/Oulu |
| Alternative name | KCC2(6.8mut)luc (=deltaNRSE) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Slc12a5*/luc)#Msa |
| Gene/Transgene symbol | Tg(Slc12a5*/luc)#Msa |
Information from provider
| Provider | Matti Airaksinen |
| Provider affiliation | Univ. Helsinki |
| Genetic information | The KCC2(6.8mut)luc is a transgenic luciferase reporter line with a genomic fragment of the Slc12a5 (KCC2) gene; similar to EMMA strain EM:14927 except for a 340bp (+355/+695) deletion in intron 1 that includes the neuron-restrictive silencer element (NRSE). The transgenic mice were produced by standard DNA pronucleus injection of fertilized FVB/N mouse strain oocytes. The transgenic strain was maintained in this background and has no obvious phenotype. |
| Phenotypic information | Homozygous:normalHeterozygous:normal |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous FVB/N males |
Literature references
- Neuronal K+/Cl- co-transporter (KCC2) transgenes lacking neurone restrictive silencer element recapitulate CNS neurone-specific expression and developmental up-regulation of endogenous KCC2 gene.;Uvarov Pavel, Pruunsild Priit, Timmusk Tõnis, Airaksinen Matti S, ;2005;Journal of neurochemistry;95;1144-55; 16271048