B6J;129S6-Gpr37l1tm1Cnrm/Cnrm
| Status | Under development - register interest |
| EMMA ID | EM:15002 |
| International strain name | B6J;129S6-Gpr37l1tm1Cnrm/Cnrm |
| Alternative name | Gpr37l1-flox/neo |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Gpr37l1tm1-flox/neo-Cnrm |
| Gene/Transgene symbol | Gpr37l1 |
Information from provider
| Provider | Daniela Marazziti |
| Provider affiliation | Istitute of Biochemistry and Cell Biology (IBBC), Consiglio Nazionale delle Ricerche (CNR) |
| Genetic information | Single loxP site inserted upstream of Gpr37l1 exon 1 and floxed neomycin-resistance cassette inserted in intron 1 by homologous recombination in ES cells. A targeted XSV1 (129S6/SvEvTac) ES cell clone was used to produce the Gpr37l1-floxed/neo mouse mutant strain. |
| Phenotypic information | No abnormal phenotype. GPR37L1 is a 7-transmembrane span protein, highly homologous to GPR37, a parkin-associated endothelin B receptor-like protein. Mammalian GPR37L1 receptors are highly expressed in various brain regions and have been reported to interact with the prosaposin glycoprotein, as well as its derived, cytoprotective peptides and analogues. In mouse cerebellar astrocytes the GPR37L1 protein is associated to patched 1, the primary cilium's sonic hedgehog coreceptor, as well as to megalencephalic leukoencephalopathy membrane proteins. |
| Breeding history | Crossed 1-2 times to C57BL/6J |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Genetic ablation of Gpr37l1 delays tumor occurrence in Ptch1+/- mouse models of medulloblastoma.;Di Pietro Chiara, La Sala Gina, Matteoni Rafaele, Marazziti Daniela, Tocchini-Valentini Glauco P, ;2019;Experimental neurology;312;33-42; 30452905
- Primary Cilia in the Murine Cerebellum and in Mutant Models of Medulloblastoma.;Di Pietro Chiara, Marazziti Daniela, La Sala Gina, Abbaszadeh Zeinab, Golini Elisabetta, Matteoni Rafaele, Tocchini-Valentini Glauco P, ;2017;Cellular and molecular neurobiology;37;145-154; 26935062
- Precocious cerebellum development and improved motor functions in mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1 receptor.;Marazziti Daniela, Di Pietro Chiara, Golini Elisabetta, Mandillo Silvia, La Sala Gina, Matteoni Rafaele, Tocchini-Valentini Glauco P, ;2013;Proceedings of the National Academy of Sciences of the United States of America;110;16486-91; 24062445
- Gpr37l1/prosaposin receptor regulates Ptch1 trafficking, Shh production, and cell proliferation in cerebellar primary astrocytes.;La Sala Gina, Di Pietro Chiara, Matteoni Rafaele, Bolasco Giulia, Marazziti Daniela, Tocchini-Valentini Glauco P, ;2020;Journal of neuroscience research;0;1649-1665; 33350496
- Identification of the GlialCAM interactome: the G protein-coupled receptors GPRC5B and GPR37L1 modulate megalencephalic leukoencephalopathy proteins.;Alonso-Gardón Marta, Elorza-Vidal Xabier, Castellanos Aida, La Sala Gina, Armand-Ugon Mercedes, Gilbert Alice, Di Pietro Chiara, Pla-Casillanis Adrià, Ciruela Francisco, Gasull Xavier, Nunes Virginia, Martínez Albert, Schulte Uwe, Cohen-Salmon Martine, Marazziti Daniela, Estévez Raúl, ;2021;Human molecular genetics;30;; 34100078