C57BL/6J-Iap5-1solo/H
| Status | Available to order |
| EMMA ID | EM:15067 |
| Citation information | RRID:IMSR_EM:15067 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6J-Iap5-1solo/H |
| Alternative name | B6J Iap5-1soloAce |
| Strain type | Spontaneous |
| Allele/Transgene symbol | Iap5-1solo |
| Gene/Transgene symbol | Iap5-1 |
Information from provider
| Provider | Anne Ferguson-Smith |
| Provider affiliation | Genetics, University of Cambridge |
| Genetic information | This strain carries the solo LTR variant of the genetically induced intracisternal A-particle, located near to coding gene Pgm2 on chromosome 5 (Iap5-1solo). This is the unmethylated variant of this locus (Iap5-1full or B6JIap5-1fullAce is the methylated variant; EMMA strain EM:15019) whose epigenetic state is established during early preimplantation. |
| Phenotypic information | Homozygous:Mild metabolic phenotype depending on the methylation at the IAP.Heterozygous:Mild metabolic phenotype depending on the methylation at the IAP. |
| Breeding history | These are maintained as a homozygous colony. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- A spontaneous genetically induced epiallele at a retrotransposon shapes host genome function.;Bertozzi Tessa M, Takahashi Nozomi, Hanin Geula, Kazachenka Anastasiya, Ferguson-Smith Anne C, ;2021;eLife;10;; 33755012