- abnormal spleen morphology / IMPC
- enlarged spleen / IMPC
- abnormal uterus morphology / IMPC
- small seminal vesicle / IMPC
- microphthalmia / IMPC
- abnormal seminal vesicle morphology / IMPC
- abnormal eye morphology / IMPC
- increased circulating creatinine level / IMPC
- increased fasting circulating glucose level / IMPC
C57BL/6NCrl-Parp1em1(IMPC)Ccpcz/Ph
Status | Under development - register interest |
EMMA ID | EM:15075 |
Citation information | RRID:IMSR_EM:15075 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | C57BL/6NCrl-Parp1em1(IMPC)Ccpcz/Ph |
Alternative name | |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Parp1em1(IMPC)Ccpcz |
Gene/Transgene symbol | Parp1 |
Information from provider
Provider | Institute of Molecular Genetics |
Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
IMPC phenotypes (allele matching)
IMPC phenotypes (gene matching)
- decreased grip strength / IMPC
- decreased total retina thickness / IMPC
- decreased NK cell number / IMPC
- preweaning lethality, incomplete penetrance / IMPC
- abnormal spleen morphology / IMPC
- abnormal uterus morphology / IMPC
- abnormal eye morphology / IMPC
- increased prepulse inhibition / IMPC
- small seminal vesicle / IMPC
- immune system phenotype / IMPC
- increased circulating creatinine level / IMPC
- increased fasting circulating glucose level / IMPC
- abnormal seminal vesicle morphology / IMPC
- microphthalmia / IMPC
- increased effector memory CD8-positive, alpha-beta T cell number / IMPC
- enlarged spleen / IMPC
- abnormal retina inner nuclear layer morphology / IMPC
MGI phenotypes (gene matching)
- decreased cell proliferation / MGI
- skin hyperplasia / MGI
- decreased body weight / MGI
- increased mortality induced by gamma-irradiation / MGI
- abnormal inflammatory response / MGI
- decreased inflammatory response / MGI
- decreased litter size / MGI
- abnormal macrophage physiology / MGI
- enhanced wound healing / MGI
- no phenotypic analysis / MGI
- abnormal leukocyte migration / MGI
- decreased neuron apoptosis / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- abnormal microglial cell physiology / MGI
- elevated level of mitotic sister chromatid exchange / MGI
- increased mortality induced by ionizing radiation / MGI
- induced chromosome breakage / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- abnormal cell cycle checkpoint function / MGI
- decreased susceptibility to noise-induced hearing loss / MGI
- decreased susceptibility to injury / MGI
- immune system phenotype / MGI
- increased renal glomerular filtration rate / MGI
- decreased circulating creatinine level / MGI
- increased apoptosis / MGI
- abnormal DNA repair / MGI
- decreased circulating tumor necrosis factor level / MGI
- decreased circulating interleukin-1 beta level / MGI
- decreased susceptibility to endotoxin shock / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- prenatal lethality, incomplete penetrance / MGI
- decreased renal tubule apoptosis / MGI
- decreased susceptibility to dopaminergic neuron neurotoxicity / MGI
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