STOCK Ts(1716)66Yah/Ics
| Status | Available to order |
| EMMA ID | EM:15096 |
| International strain name | STOCK Ts(1716)66Yah/Ics |
| Alternative name | B6C3B Ts66Yah |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Ts(1716)66Yah, |
| Gene/Transgene symbol | Ts(17<16>)66Yah |
Information from provider
| Provider | Yann HERAULT |
| Provider affiliation | CERBM GIE |
| Genetic information | An upgraded Down syndrome model, carrying a segregating mini-chromosome, trisomic for a region encompassing the Mir155 to Zbtb21 genes homologous to human chromosome 21 and linked to the centromeric region of mouse chromosome 17 with no genes. |
| Phenotypic information | Homozygous:Not available.Heterozygous:Changes in behaviour and cognition, craniofacial phenotypes and hippocampal gene expression observed in trisomic individuals. |
| Breeding history | Kept in an F1 B6C3B genetic background, with the C57BL/6J and the C3B line as a C3H/HeN congenic line for the BALB/c allele at the Pde6b locus (Hart et al., 2005; Hoelter et al., 2008) |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
MGI allele-associated human disease models
Literature references
- Ts66Yah, a mouse model of Down syndrome with improved construct and face validity.;Duchon Arnaud, Del Mar Muñiz Moreno Maria, Chevalier Claire, Nalesso Valérie, Andre Philippe, Fructuoso-Castellar Marta, Mondino Mary, Po Chrystelle, Noblet Vincent, Birling Marie-Christine, Potier Marie-Claude, Herault Yann, ;2022;Disease models & mechanisms;15;; 36374158