B6.Cg-Nfat5^tm1.1Joar/Cnbc

Status	Available to order
EMMA ID	EM:15109
International strain name	B6.Cg-Nfat5^tm1.1Joar/Cnbc
Alternative name	NFAT5 floxed mice
Strain type	Targeted Mutant Strains : Conditional mutation
Allele/Transgene symbol	Nfat5^tm1.1Joar,
Gene/Transgene symbol	Nfat5

Information from provider

Provider	Cristina Lopez Rodriguez
Provider affiliation	Universitat Pompeu Fabra
Genetic information	Exon 6 of the Nfat5 gene was flanked by loxP sites by homologous recombination in C57BL/6 embryonic stem cells (Bruce 4). Original reference: Drews-Elger et al. PLoS ONE 2009
Phenotypic information	Homozygous: No obvious phenotype unless immune responses are induced. The full Nfat5 knockout is expected to be embryonic lethal in the C57BL/6 genetic background. Nfat5 floxed mice are healthy, with no phenotype. In our hands, conditional Nfat5 knockouts in different immune cell subtypes, are healthy. Heterozygous: No observed phenotype.
Breeding history	Mutant mice were generated by homologous recombination in C57BL/6 embryonic stem cells (Bruce 4) and performing several backcrosses (more than 10 generations) to C57BL/6
References	The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress.;Drews-Elger Katherine, Ortells M Carmen, Rao Anjana, López-Rodriguez Cristina, Aramburu Jose, ;2009;PloS one;4;e5245; 19381288 NFAT5 Controls the Integrity of Epidermis.;Muhammad Khalid, Xavier Delicia, Klein-Hessling Stefan, Azeem Muhammad, Rauschenberger Tabea, Murti Krisna, Avots Andris, Goebeler Matthias, Klein Matthias, Bopp Tobias, Sielaff Malte, Tenzer Stefan, Möckel Sigrid, Aramburu José, López-Rodríguez Cristina, Kerstan Andreas, Serfling Edgar, ;2021;Frontiers in immunology;12;780727; 34956208 Salt-Sensitive Hypertension of the Renal Tubular Cell-Specific NFAT5 (Nuclear Factor of Activated T-Cells 5) Knockout Mice.;Hiramatsu Akiko, Izumi Yuichiro, Eguchi Koji, Matsuo Naomi, Deng Qinyuan, Inoue Hideki, Nakayama Yushi, Nonoguchi Hiroshi, Aramburu Jose, López-Rodríguez Cristina, Kakizoe Yutaka, Adachi Masataka, Kuwabara Takashige, Kim-Mitsuyama Shokei, Mukoyama Masashi, ;2021;Hypertension (Dallas, Tex. : 1979);78;1335-1346; 34601973 The transcription factor NFAT5 limits infection-induced type I interferon responses.;Huerga Encabo Hector, Traveset Laia, Argilaguet Jordi, Angulo Ana, Nistal-Villán Estanislao, Jaiswal Rahul, Escalante Carlos R, Gekas Christos, Meyerhans Andreas, Aramburu Jose, López-Rodríguez Cristina, ;2020;The Journal of experimental medicine;217;2901-2918; 31816635 Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5.;Buxadé Maria, Huerga Encabo Hector, Riera-Borrull Marta, Quintana-Gallardo Lucía, López-Cotarelo Pilar, Tellechea Mónica, Martínez-Martínez Sara, Redondo Juan Miguel, Martín-Caballero Juan, Flores Juana María, Bosch Elena, Rodríguez-Fernández José Luis, Aramburu Jose, López-Rodríguez Cristina, ;2018;The Journal of experimental medicine;215;101; 30327417 Analgesia linked to Nav1.7 loss of function requires µ- and δ-opioid receptors.;Pereira Vanessa, Millet Queensta, Aramburu Jose, Lopez-Rodriguez Cristina, Gaveriaux-Ruff Claire, Wood John N, ;2018;Wellcome open research;3;305-315; 30271888 NFAT5-Regulated Macrophage Polarization Supports the Proinflammatory Function of Macrophages and T Lymphocytes.;Tellechea Mónica, Buxadé Maria, Tejedor Sonia, Aramburu Jose, López-Rodríguez Cristina, ;2018;Journal of immunology (Baltimore, Md. : 1950);200;56-67; 29150563 Context-dependent regulation of Th17-associated genes and IFNγ expression by the transcription factor NFAT5.;Alberdi Maria, Iglesias Marcos, Tejedor Sonia, Merino Ramón, López-Rodríguez Cristina, Aramburu Jose, ;2017;Immunology and cell biology;95;; 27479742
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Literature references

The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress.;Drews-Elger Katherine, Ortells M Carmen, Rao Anjana, López-Rodriguez Cristina, Aramburu Jose, ;2009;PloS one;4;e5245; 19381288
NFAT5 Controls the Integrity of Epidermis.;Muhammad Khalid, Xavier Delicia, Klein-Hessling Stefan, Azeem Muhammad, Rauschenberger Tabea, Murti Krisna, Avots Andris, Goebeler Matthias, Klein Matthias, Bopp Tobias, Sielaff Malte, Tenzer Stefan, Möckel Sigrid, Aramburu José, López-Rodríguez Cristina, Kerstan Andreas, Serfling Edgar, ;2021;Frontiers in immunology;12;780727; 34956208
Salt-Sensitive Hypertension of the Renal Tubular Cell-Specific NFAT5 (Nuclear Factor of Activated T-Cells 5) Knockout Mice.;Hiramatsu Akiko, Izumi Yuichiro, Eguchi Koji, Matsuo Naomi, Deng Qinyuan, Inoue Hideki, Nakayama Yushi, Nonoguchi Hiroshi, Aramburu Jose, López-Rodríguez Cristina, Kakizoe Yutaka, Adachi Masataka, Kuwabara Takashige, Kim-Mitsuyama Shokei, Mukoyama Masashi, ;2021;Hypertension (Dallas, Tex. : 1979);78;1335-1346; 34601973
The transcription factor NFAT5 limits infection-induced type I interferon responses.;Huerga Encabo Hector, Traveset Laia, Argilaguet Jordi, Angulo Ana, Nistal-Villán Estanislao, Jaiswal Rahul, Escalante Carlos R, Gekas Christos, Meyerhans Andreas, Aramburu Jose, López-Rodríguez Cristina, ;2020;The Journal of experimental medicine;217;2901-2918; 31816635
Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5.;Buxadé Maria, Huerga Encabo Hector, Riera-Borrull Marta, Quintana-Gallardo Lucía, López-Cotarelo Pilar, Tellechea Mónica, Martínez-Martínez Sara, Redondo Juan Miguel, Martín-Caballero Juan, Flores Juana María, Bosch Elena, Rodríguez-Fernández José Luis, Aramburu Jose, López-Rodríguez Cristina, ;2018;The Journal of experimental medicine;215;101; 30327417
Analgesia linked to Nav1.7 loss of function requires µ- and δ-opioid receptors.;Pereira Vanessa, Millet Queensta, Aramburu Jose, Lopez-Rodriguez Cristina, Gaveriaux-Ruff Claire, Wood John N, ;2018;Wellcome open research;3;305-315; 30271888
NFAT5-Regulated Macrophage Polarization Supports the Proinflammatory Function of Macrophages and T Lymphocytes.;Tellechea Mónica, Buxadé Maria, Tejedor Sonia, Aramburu Jose, López-Rodríguez Cristina, ;2018;Journal of immunology (Baltimore, Md. : 1950);200;56-67; 29150563
Context-dependent regulation of Th17-associated genes and IFNγ expression by the transcription factor NFAT5.;Alberdi Maria, Iglesias Marcos, Tejedor Sonia, Merino Ramón, López-Rodríguez Cristina, Aramburu Jose, ;2017;Immunology and cell biology;95;; 27479742

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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B6.Cg-Nfat5tm1.1Joar/Cnbc