B6.129S2-Mtf2^{Gt(U3Betageo)1Ruiz}/Cnrm

Status	Available to order
EMMA ID	EM:01517
Citation information	RRID:IMSR_EM:01517 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.129S2-Mtf2^{Gt(U3Betageo)1Ruiz}/Cnrm
Alternative name	M016A06
Strain type	Gene-trap
Allele/Transgene symbol	Mtf2^{Gt(U3Betageo)1Ruiz}
Gene/Transgene symbol	Mtf2

Information from provider

Provider	Harald von Melchner
Provider affiliation	University of Frankfurt Medical School
Genetic information	Disruption of exon 3 of the Mtf2 gene by the U3bgeo retroviral gene trap vector.
Phenotypic information	Skeletal abnormalities (abnormal head shape, bent nasal bone, C1 fused to C2), significant growth retardation, perinatal lethality with incomplete penetrance (phenotype reminiscent of bromodomain containing protein 4, Brd4, mutants), inflammatory infiltrates in liver, degenerative changes in skeletal muscle (loss of stria associated with regenerative proliferation).
Breeding history	Backcrossed over 6 generations.
References	A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.;Hansen Jens, Floss Thomas, Van Sloun Petra, Füchtbauer Ernst-Martin, Vauti Franz, Arnold Hans-Hennig, Schnütgen Frank, Wurst Wolfgang, von Melchner Harald, Ruiz Patricia, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;9918-22; 12904583 Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4.;Houzelstein Denis, Bullock Simon L, Lynch Denise E, Grigorieva Elena F, Wilson Valerie A, Beddington Rosa S P, ;2002;Molecular and cellular biology;22;3794-802; 11997514

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)

abnormal sternum morphology / MGI
increased rib number / MGI
abnormal axial skeleton morphology / MGI
vertebral transformation / MGI
cervical vertebral transformation / MGI
lumbar vertebral transformation / MGI
thoracic vertebral transformation / MGI
abnormal odontoid process morphology / MGI
delayed cellular replicative senescence / MGI
postnatal lethality, complete penetrance / MGI
decreased body size / MGI

MGI phenotypes (gene matching)

abnormal sternum morphology / MGI
kyphosis / MGI
increased rib number / MGI
kinked tail / MGI
decreased body weight / MGI
decreased body size / MGI
postnatal growth retardation / MGI
hydroencephaly / MGI
decreased litter size / MGI
abnormal axial skeleton morphology / MGI
vertebral transformation / MGI
cervical vertebral transformation / MGI
lumbar vertebral transformation / MGI
thoracic vertebral transformation / MGI
abnormal odontoid process morphology / MGI
abnormal incisor morphology / MGI
embryo phenotype / MGI
delayed cellular replicative senescence / MGI
postnatal lethality, complete penetrance / MGI
misaligned incisors / MGI

Literature references

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.;Hansen Jens, Floss Thomas, Van Sloun Petra, Füchtbauer Ernst-Martin, Vauti Franz, Arnold Hans-Hennig, Schnütgen Frank, Wurst Wolfgang, von Melchner Harald, Ruiz Patricia, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;9918-22; 12904583
Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4.;Houzelstein Denis, Bullock Simon L, Lynch Denise E, Grigorieva Elena F, Wilson Valerie A, Beddington Rosa S P, ;2002;Molecular and cellular biology;22;3794-802; 11997514
Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes.;Li Xiangzhi, Isono Kyo-Ichi, Yamada Daisuke, Endo Takaho A, Endoh Mitsuhiro, Shinga Jun, Mizutani-Koseki Yoko, Otte Arie P, Casanova Miguel, Kitamura Hiroshi, Kamijo Takehiko, Sharif Jafar, Ohara Osamu, Toyada Tetsuro, Bernstein Bradley E, Brockdorff Neil, Koseki Haruhiko, ;2011;Molecular and cellular biology;31;351-64; 21059868

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
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Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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B6.129S2-Mtf2Gt(U3Betageo)1Ruiz/Cnrm