B6.129S2-Mtf2Gt(U3Betageo)1Ruiz/Cnrm

Status

Available to order

EMMA IDEM:01517
International strain nameB6.129S2-Mtf2Gt(U3Betageo)1Ruiz/Cnrm
Alternative nameM016A06
Strain typeGene-trap
Allele/Transgene symbolMtf2Gt(U3Betageo)1Ruiz,
Gene/Transgene symbolMtf2

Information from provider

ProviderHarald von Melchner
Provider affiliationUniversity of Frankfurt Medical School
Genetic informationDisruption of exon 3 of the Mtf2 gene by the U3bgeo retroviral gene trap vector.
Phenotypic informationSkeletal abnormalities (abnormal head shape, bent nasal bone, C1 fused to C2), significant growth retardation, perinatal lethality with incomplete penetrance (phenotype reminiscent of bromodomain containing protein 4, Brd4, mutants), inflammatory infiltrates in liver, degenerative changes in skeletal muscle (loss of stria associated with regenerative proliferation).
Breeding historyBackcrossed over 6 generations.
References
  • A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.;Hansen Jens, Floss Thomas, Van Sloun Petra, Füchtbauer Ernst-Martin, Vauti Franz, Arnold Hans-Hennig, Schnütgen Frank, Wurst Wolfgang, von Melchner Harald, Ruiz Patricia, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;9918-22; 12904583
  • Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4.;Houzelstein Denis, Bullock Simon L, Lynch Denise E, Grigorieva Elena F, Wilson Valerie A, Beddington Rosa S P, ;2002;Molecular and cellular biology;22;3794-802; 11997514

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal sternum morphology / MGI
  • increased rib number / MGI
  • abnormal axial skeleton morphology / MGI
  • vertebral transformation / MGI
  • cervical vertebral transformation / MGI
  • lumbar vertebral transformation / MGI
  • thoracic vertebral transformation / MGI
  • abnormal odontoid process morphology / MGI
  • delayed cellular replicative senescence / MGI
  • postnatal lethality, complete penetrance / MGI
  • decreased body size / MGI

Literature references

  • A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.;Hansen Jens, Floss Thomas, Van Sloun Petra, Füchtbauer Ernst-Martin, Vauti Franz, Arnold Hans-Hennig, Schnütgen Frank, Wurst Wolfgang, von Melchner Harald, Ruiz Patricia, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;9918-22; 12904583
  • Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4.;Houzelstein Denis, Bullock Simon L, Lynch Denise E, Grigorieva Elena F, Wilson Valerie A, Beddington Rosa S P, ;2002;Molecular and cellular biology;22;3794-802; 11997514

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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