Sprague Dawley rat Tg(prp-TBP)Q38
| Status | Available to order |
| EMMA ID | EM:15170 |
| International strain name | Sprague Dawley rat Tg(prp-TBP)Q38 |
| Alternative name | SPRD-tg(prp-TBP)Q38 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(prp-TBP)Q38 |
| Gene/Transgene symbol | Tg(prp-TBP)Q38 |
Information from provider
| Provider | Huu Phuc Nguyen |
| Provider affiliation | Human Genetik, Ruhr Universität Bochum |
| Genetic information | SPRD-tg(prp-TBP)Q38 rats carry the wild-type human TATA-Box Binding Protein (TBP) gene with 38 CAG repeats. The transgene construct contains a fragment of the murine prion promoter (Prp), an N-terminal myc tag, full-length human TBP cDNA, and a poly-A tail. |
| Phenotypic information | Homozygous:So far there was no homozygous SPRD-tg(prp-TBP)Q38 rat bredHeterozygous:SPRD-tg(prp-TBP)Q38 heterozygous rats do not show any phenotypic abnormalities compared to wild-type littermates |
| Breeding history | approximately 25 generations |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous rat Sprague-Dawley , wild-type rat Sprague-Dawley Charles River Laboratories |
| Stage of embryos | 2-cell |
Literature references
- A novel transgenic rat model for spinocerebellar ataxia type 17 recapitulates neuropathological changes and supplies in vivo imaging biomarkers.;Kelp Alexandra, Koeppen Arnulf H, Petrasch-Parwez Elisabeth, Calaminus Carsten, Bauer Claudia, Portal Esteban, Yu-Taeger Libo, Pichler Bernd, Bauer Peter, Riess Olaf, Nguyen Huu Phuc, ;2013;The Journal of neuroscience : the official journal of the Society for Neuroscience;33;9068-81; 23699518