Tmprss9+/delta
| Status | Available to order |
| EMMA ID | EM:15179 |
| Citation information | RRID:IMSR_EM:15179 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | Tmprss9+/delta |
| Alternative name | Tmprss9+/delta |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Tmprss9em-del |
| Gene/Transgene symbol | Tmprss9 |
Information from provider
| Provider | Edith Hummler |
| Provider affiliation | Department of Biomedical Sciences, UNIL |
| Genetic information | Deletion of exon 3 generated by CRISPR/Cas9 technology. |
| Phenotypic information | Homozygous:No phenotype.Heterozygous:No phenotype. |
| Breeding history | Particular attention was paid to the design of the sgRNAs through the transgenic service (University of Zurich, Switzerland) in order to obtain a none-to-low off-target score. Once the mice had been obtained in 2019, we have immediately performed back-crossing with C57BL/6N wild-type mice and started the experiments for the recent publication from N=6-7 onwards. Meanwhile, we are at N=10 generations. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6N males |
Literature references
- Combination of genetic studies and animal modeling proposes TMPRSS9 as a candidate gene for serum K+ variations.;Auberson Muriel, Wang Dongmei, Ehret Elodie, Corre Tanguy, Anand Deepika, Mechakra Asma, Staub Olivier, Bochud Murielle, Hummler Edith, ;2025;Scientific reports;15;25211; 40652049