STOCK Cfap43em1.2Gos/BiatPh
| Status | Only small colony available |
| EMMA ID | EM:15183 |
| Citation information | RRID:IMSR_EM:15183 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Cfap43em1.2Gos/BiatPh |
| Alternative name | Cfap43Δex3/Δex3 |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Cfap43em1.2Gos |
| Gene/Transgene symbol | Cfap43 |
Information from provider
| Provider | Achim Gossler |
| Provider affiliation | MHH |
| Genetic information | The cre recombinase-mediated deletion of exon 3 leads to frame-shift and premature stop. |
| Phenotypic information | Homozygous:Male sterility, hydrocephalus, mucus accumulation in nasal cavity, ciliary beat frequency of tracheal multiciliated cells (MCCs) increased, flow decreased.Heterozygous:no detected phenotype. |
| Breeding history | More than 10 generations including CD1 and 129/Sv. |
| References |
|
| Homozygous fertile | females only |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
| Animals used for archiving | homozygous Other (please specify below) males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Non-syndromic male infertility due to sperm motility disorder / Orphanet_276234
Literature references
- CFAP43 modulates ciliary beating in mouse and Xenopus.;Rachev Ev, Schuster-Gossler Karin, Fuhl Franziska, Ott Tim, Tveriakhina Lena, Beckers Anja, Hegermann Jan, Boldt Karsten, Mai Michaela, Kremmer Elisabeth, Ueffing Marius, Blum Martin, Gossler Achim, ;2020;Developmental biology;459;109-125; 31884020