B6Brd;B6N-Tyr^c-Brd Krt76^{tm1a(KOMP)Wtsi}/WtsiPh

Status	Under development - register interest
EMMA ID	EM:15230
Citation information	RRID:IMSR_EM:15230 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6Brd;B6N-Tyr^c-Brd Krt76^{tm1a(KOMP)Wtsi}/WtsiPh
Alternative name	EPD0106_2_B05
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Krt76^{tm1a(KOMP)Wtsi}
Gene/Transgene symbol	Krt76
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from KOMP ES clone EPD0106_2_B05. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.;Liakath-Ali Kifayathullah, Vancollie Valerie E, Heath Emma, Smedley Damian P, Estabel Jeanne, Sunter David, Ditommaso Tia, White Jacqueline K, Ramirez-Solis Ramiro, Smyth Ian, Steel Karen P, Watt Fiona M, ;2014;Nature communications;5;3540; 24721909 Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.;DiTommaso Tia, Jones Lynelle K, Cottle Denny L, null null, Gerdin Anna-Karin, Vancollie Valerie E, Watt Fiona M, Ramirez-Solis Ramiro, Bradley Allan, Steel Karen P, Sundberg John P, White Jacqueline K, Smyth Ian M, ;2014;PLoS genetics;10;e1004705; 25340873

Information from EMMA

Archiving centre	Institute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

IMPC phenotypes (allele matching)

developmental dysplasia / IMPC

IMPC phenotypes (gene matching)

developmental dysplasia / IMPC

MGI phenotypes (allele matching)

abnormal coat appearance / MGI
abnormal hair cycle / MGI
increased foot pad pigmentation / MGI
abnormal sebaceous gland morphology / MGI
enlarged sebaceous gland / MGI
flaky skin / MGI
abnormal epidermal layer morphology / MGI
thick epidermis / MGI
abnormal epidermis stratum basale morphology / MGI
abnormal tail morphology / MGI
increased tail pigmentation / MGI

MGI phenotypes (gene matching)

abnormal hair cycle / MGI
increased foot pad pigmentation / MGI
abnormal sebaceous gland morphology / MGI
enlarged sebaceous gland / MGI
flaky skin / MGI
abnormal epidermal layer morphology / MGI
thick epidermis / MGI
abnormal epidermis stratum basale morphology / MGI
abnormal coat appearance / MGI
abnormal tail morphology / MGI
increased tail pigmentation / MGI

Literature references

Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.;Liakath-Ali Kifayathullah, Vancollie Valerie E, Heath Emma, Smedley Damian P, Estabel Jeanne, Sunter David, Ditommaso Tia, White Jacqueline K, Ramirez-Solis Ramiro, Smyth Ian, Steel Karen P, Watt Fiona M, ;2014;Nature communications;5;3540; 24721909
Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.;DiTommaso Tia, Jones Lynelle K, Cottle Denny L, null null, Gerdin Anna-Karin, Vancollie Valerie E, Watt Fiona M, Ramirez-Solis Ramiro, Bradley Allan, Steel Karen P, Sundberg John P, White Jacqueline K, Smyth Ian M, ;2014;PLoS genetics;10;e1004705; 25340873

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.

B6Brd;B6N-Tyrc-Brd Krt76tm1a(KOMP)Wtsi/WtsiPh