IMPC phenotypes (gene matching)
B6;129-Spo11tm(Spo11-beta_b)Mbrc/Cnrm
| Status | Under development - register interest |
| EMMA ID | EM:15268 |
| Citation information | RRID:IMSR_EM:15268 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-Spo11tm(Spo11-beta_b)Mbrc/Cnrm |
| Alternative name | C57/129Spo11_beta_b_ki/+ |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Spo11beta-b_ki |
| Gene/Transgene symbol | Spo11 |
Information from provider
| Provider | Marco Barchi |
| Provider affiliation | Biomedicine and Prevention, University of Rome Tor Vergata |
| Genetic information | B6/129 Spo11_beta_b_ki/+ is a knock-in hemizygous for the Spo11_bet_b splice isoform. It has been generated by knocking-in the Spo11_beta-b cDNA into the Spo11 locus, destroying the ATG in exon 1. |
| Phenotypic information | Homozygous:Unknown.Heterozygous:Healthy, most males are fertile beside increased missegregation of XY chromosomes. Frequency of XY asynapsis varies among mice from about 10% to 60%. Females are fully fertile. |
| Breeding history | Knock-in construct introduced in A9 ES cells (C57BL/6 and 129 background), then mutant mice crossed with Spo11+/- mice with mixed C57BL/6 and 129 backgrounds. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal female reproductive system morphology / MGI
- abnormal ovary morphology / MGI
- small ovary / MGI
- impaired ovarian folliculogenesis / MGI
- absent mature ovarian follicles / MGI
- abnormal male reproductive system morphology / MGI
- small testis / MGI
- small seminiferous tubules / MGI
- arrest of spermatogenesis / MGI
- abnormal spermatogenesis / MGI
- male infertility / MGI
- female infertility / MGI
- abnormal gametogenesis / MGI
- abnormal meiosis / MGI
- abnormal oogenesis / MGI
- abnormal reproductive system morphology / MGI
- abnormal fertility/fecundity / MGI
- abnormal seminiferous tubule morphology / MGI
- decreased mature ovarian follicle number / MGI
- abnormal uterus development / MGI
- decreased testis weight / MGI
- decreased ovary weight / MGI
- azoospermia / MGI
- abnormal female meiosis / MGI
- abnormal male meiosis / MGI
- immune system phenotype / MGI
- decreased oocyte number / MGI
- abnormal spermatid morphology / MGI
- arrest of male meiosis / MGI
- early reproductive senescence / MGI
- oocyte degeneration / MGI
- abnormal primordial ovarian follicle morphology / MGI
- abnormal chromosomal synapsis / MGI
- abnormal synaptonemal complex / MGI
- abnormal double-strand DNA break repair / MGI
- abnormal X-Y chromosome synapsis during male meiosis / MGI