Rho-P347L
| Status | Available to order |
| EMMA ID | EM:15273 |
| Citation information | RRID:IMSR_EM:15273 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | Rho-P347L |
| Alternative name | Rho-P347L |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Rho (rhodopsin) P347L change |
| Gene/Transgene symbol | Rho |
Information from provider
| Provider | Miike Cheetham |
| Provider affiliation | UCL Insitute of Ophthalmology, UCL |
| Genetic information | Rhodopsin knock-in of P347L amino acid substitution using CRISPR/Cas9 technology. |
| Phenotypic information | Homozygous:Strong retinal dysfunction and rapid retinal degeneration.Heterozygous:Retinal dysfunction and retinal degeneration. |
| Breeding history | The line was produced in C57BL/6J but it has also been crossed to control C57BL/6J for over 10 generations to ensure no unlinked CRISPR off target effects. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |