Rho-T58R
| Status | Available to order |
| EMMA ID | EM:15275 |
| Citation information | RRID:IMSR_EM:15275 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | Rho-T58R |
| Alternative name | Rho-T58R |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Rho (rhodopsin) T58R change |
| Gene/Transgene symbol | Rho |
Information from provider
| Provider | Mike Cheetham |
| Provider affiliation | UCL Insitute of Ophthalmology, UCL |
| Genetic information | Rhodopsin knock-in of T58R amino acid substitution using CRISPR/Cas9 technology |
| Phenotypic information | Homozygous:Retinal dysfunction and retinal degeneration, which is accelerated by bright light exposureHeterozygous:Light dependent retinal dysfunction and retinal degeneration |
| Breeding history | The line was produced in C57BL/6J but has also been crossed to control C57BL/6J for over 10 generations to ensure no unlinked CRISPR off target effects. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |