| Status | Under development - register interest |
| EMMA ID | EM:15300 |
| International strain name | FVB/N(Cg)-H2b/Orl |
| Alternative name | FVBN/H2b |
| Strain type | Other |
| Allele/Transgene symbol | H2b, |
| Gene/Transgene symbol | H2 |
| Provider | Douglas hanahan |
| Provider affiliation | SV, EPFL/ISREC/Ludwig Lausanne |
| Genetic information | FVB/N-H2b |
| Phenotypic information | Homozygous:These mice do not develop abnormal phenotypes. They are inbred mice of the FVB/N genetic background that are homozygous congenic for the H2b MHC locus.Heterozygous:Not applicable. |
| Breeding history | C57BL/6 (H2b) mice were bred with FVB/N mice, and the F1 mice were backcrossed to FVB/N to generate mice congenic for the H2b MHC locus but otherwise genetically FVB/N. Thus the F1 mice were backcrossed for 11 generations to FVB/N, selecting for the H2b locus in every generation by flow cytometry analyses of H2Kb and H2Db. Subsequently, N11 backcross mice were intercrossed to generate homozygous H2b mice, expressing H2Kb and H2Db, but not H2Kq and H2D/Lq. The homozygous H2b congenics were then established as an inbred line by breeding males and females of this genotype. More than 20 crosses. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous FVB/N, homozygous FVB/N |
| Stage of embryos | 2-cell |
