- increased circulating alanine transaminase level / IMPC
- hyperactivity / IMPC
- decreased thigmotaxis / IMPC
- decreased anxiety-related response / IMPC
- increased grip strength / IMPC
- decreased circulating fructosamine level / IMPC
- increased circulating phosphate level / IMPC
- abnormal behavior / IMPC
- decreased circulating total protein level / IMPC
- abnormal locomotor behavior / IMPC
- decreased circulating serum albumin level / IMPC
B6NTac;B6N-Comttm1c(EUCOMM)Wtsi/Orl
Status | Available to order |
EMMA ID | EM:15430 |
Citation information | RRID:IMSR_EM:15430 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | B6NTac;B6N-Comttm1c(EUCOMM)Wtsi/Orl |
Alternative name | Comt-tm1c |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Comttm1c(EUCOMM)Wtsi |
Gene/Transgene symbol | Comt |
Information from provider
Provider | Cécile FREMOND |
Provider affiliation | CNRS-TAAM-UAR44 |
Genetic information | This mouse line originates from EUCOMM ES clone EPD0350_1_G06. For further details on the construction of this clone see the relevant page at the IMPC portal (https://www.mousephenotype.org/data/alleles/MGI:88470/tm1a(EUCOMM)Wtsi). |
Phenotypic information | Homozygous mice have not been generated. |
Breeding history | Rederived mice carrying the Comttm1a(EUCOMM)Wtsi mutation, have been crossed with flp deleter mice (B6N-Gt(ROSA)26Sortm2(CAG-flpo,-EYFP)Ics/Ics, EMMA strain EM:05490) to obtain the Comttm1c(EUCOMM)Wtsi allele. |
References | None available |
Homozygous fertile | not known |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | heterozygous C57BL/6NTac males |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- hypertension / MGI
- increased aggression towards males / MGI
- increased anxiety-related response / MGI
- increased startle reflex / MGI
- decreased startle reflex / MGI
- abnormal placenta morphology / MGI
- abnormal homeostasis / MGI
- increased dopamine level / MGI
- abnormal fertility/fecundity / MGI
- short gestation period / MGI
- increased vertical activity / MGI
- decreased vertical activity / MGI
- albuminuria / MGI
- abnormal fear-related response / MGI
- abnormal placenta vasculature / MGI
- abnormal response to novel object / MGI
- abnormal spongiotrophoblast layer morphology / MGI
- abnormal maternal decidual layer morphology / MGI
- hypoxia / MGI
- abnormal renal glomerulus morphology / MGI
- behavior/neurological phenotype / MGI
- abnormal spatial working memory / MGI
- increased interferon-gamma secretion / MGI
- abnormal xenobiotic pharmacokinetics / MGI
- increased prepulse inhibition / MGI
- decreased prepulse inhibition / MGI
- increased uterine NK cell number / MGI
- enhanced contextual conditioning behavior / MGI
- impaired contextual conditioning behavior / MGI
- enhanced cued conditioning behavior / MGI
- impaired cued conditioning behavior / MGI
- abnormal blood homeostasis / MGI
- abnormal pregnancy / MGI
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