C57BL/6N-Fshrtm1.2(cre)Ics/Ics
Status | Available to order |
EMMA ID | EM:15550 |
International strain name | C57BL/6N-Fshrtm1.2(cre)Ics/Ics |
Alternative name | Fshrtm1.2(cre)Ics |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Fshrtm1.2(cre)Ics |
Gene/Transgene symbol | Fshr |
Information from provider
Provider | ICS, Institut Clinique de la Souris |
Provider affiliation | ICS, Institut Clinique de la Souris |
Genetic information | This line was obtained by crossing Fshrtm1.1(cre/ERT2)Ics animals with the C57BL/6NTac-Gt(ROSA)26Sor-tm2(CAG-flpo,-EYFP)Ics flp ubiquitous deleter (EMMA strain ID EM:05490), resulting in an IRES-cre-F3 sequence located into the 3' UTR region of the Fshr gene. The pure C57BL/6N background was maintained for all breeding steps. Efficiency of deletion was confirmed by crossing this line with the fluorescent reporter of cre expression Gt(ROSA)26Sor-tm4(ACTB-tdTomato,-EGFP)Luo. A specific EGFP signal was observed in the ovaries and no signal was observed in the control organ (liver). Analysis of mRNA expression showed that tm1.2 allele (cre probe) mRNA is also expressed at an expected level in the ovaries. For detailed information on the genetic description of this strain, please have a look at this report. |
Phenotypic information | Homozygous:NAHeterozygous:NA |
Breeding history | C57BL/6N inbred (3 generations). |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- 46,XX gonadal dysgenesis / Orphanet_243
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