C57BL/6NTac-Setd1atm1c(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:15687
Citation informationRRID:IMSR_EM:15687 

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International strain nameC57BL/6NTac-Setd1atm1c(EUCOMM)Wtsi/H
Alternative nameC57BL/6NTac-Setd1a/H
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolSetd1atm1c(EUCOMM)Wtsi
Gene/Transgene symbolSetd1a

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThe L1L2_gt0 cassette was inserted at position 127379089 of Chromosome 7 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 127380049. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). The tm1c allele was generated using Flp recombinase to excise the lacZ-neomycin cassette present in the tm1a allele. The tm1c allele still carries loxP sites available for excision by cre recombinase.
Phenotypic informationHomozygous:
No abnormal phenotype reported

Heterozygous:
No abnormal phenotype reported
References
  • Setd1a regulates progenitor B-cell-to-precursor B-cell development through histone H3 lysine 4 trimethylation and Ig heavy-chain rearrangement.;Tusi Betsabeh Khoramian, Deng Changwang, Salz Tal, Zeumer Leilani, Li Yangqiu, So Chi Wai Eric, Morel Laurence M, Qiu Yi, Huang Suming, ;2015;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;29;1505-15; 25550471
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • lymphoid neoplasms / IMPC
  • hyperplasia / IMPC
  • increased blood urea nitrogen level / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • decreased leukocyte cell number / IMPC
  • decreased circulating LDL cholesterol level / IMPC
  • increased circulating fructosamine level / IMPC
  • decreased circulating cholesterol level / IMPC
  • increased circulating creatinine level / IMPC
  • decreased total body fat amount / IMPC
  • increased bone mineral density / IMPC
  • neoplasm / IMPC
MGI phenotypes (gene matching)
  • increased bone mineral density / MGI
  • decreased circulating LDL cholesterol level / MGI
  • decreased circulating HDL cholesterol level / MGI
  • decreased leukocyte cell number / MGI
  • failure to gastrulate / MGI
  • decreased circulating alanine transaminase level / MGI
  • decreased circulating alkaline phosphatase level / MGI
  • decreased rib number / MGI
  • decreased circulating cholesterol level / MGI
  • cellular phenotype / MGI
  • abnormal cell physiology / MGI
  • abnormal DNA methylation / MGI
  • decreased total body fat amount / MGI
  • embryonic lethality between implantation and somite formation, complete penetrance / MGI

Literature references

  • Setd1a regulates progenitor B-cell-to-precursor B-cell development through histone H3 lysine 4 trimethylation and Ig heavy-chain rearrangement.;Tusi Betsabeh Khoramian, Deng Changwang, Salz Tal, Zeumer Leilani, Li Yangqiu, So Chi Wai Eric, Morel Laurence M, Qiu Yi, Huang Suming, ;2015;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;29;1505-15; 25550471

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

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Practical information

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