IMPC phenotypes (gene matching)
- preweaning lethality, complete penetrance / IMPC
C57BL/6NCrl-Fynem1(IMPC)Ccpcz/Ph
| Status | Under development - register interest |
| EMMA ID | EM:15728 |
| Citation information | RRID:IMSR_EM:15728 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NCrl-Fynem1(IMPC)Ccpcz/Ph |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Fynem1(IMPC)Ccpcz |
| Gene/Transgene symbol | Fyn |
Information from provider
| Provider | Institute of Molecular Genetics |
| Provider affiliation | Department of Transgenic Models of Diseases, Institute of Molecular Genetics |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased corpus callosum size / MGI
- abnormal stratification in cerebral cortex / MGI
- abnormal hippocampus morphology / MGI
- abnormal dentate gyrus morphology / MGI
- abnormal hippocampus layer morphology / MGI
- abnormal olfactory bulb morphology / MGI
- abnormal hypothalamus morphology / MGI
- abnormal somatosensory cortex morphology / MGI
- abnormal myelination / MGI
- small seminiferous tubules / MGI
- abnormal optic nerve morphology / MGI
- abnormal pup retrieval / MGI
- abnormal maternal nurturing / MGI
- abnormal suckling behavior / MGI
- abnormal spatial learning / MGI
- reduced long term potentiation / MGI
- abnormal startle reflex / MGI
- audiogenic seizures / MGI
- abnormal immune cell physiology / MGI
- abnormal T cell activation / MGI
- increased dopamine level / MGI
- abnormal olfaction / MGI
- abnormal seminiferous tubule morphology / MGI
- abnormal T cell physiology / MGI
- abnormal macrophage physiology / MGI
- abnormal eosinophil physiology / MGI
- decreased IgE level / MGI
- increased IgM level / MGI
- oligozoospermia / MGI
- abnormal excitatory postsynaptic potential / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- increased fear-related response / MGI
- abnormal thymocyte activation / MGI
- enhanced passive avoidance behavior / MGI
- increased susceptibility to experimental autoimmune uveoretinitis / MGI
- decreased testis weight / MGI
- abnormal T cell clonal deletion / MGI
- decreased T cell number / MGI
- abnormal T cell proliferation / MGI
- decreased T cell proliferation / MGI
- abnormal CD4-positive, alpha-beta T cell physiology / MGI
- increased susceptibility to type I hypersensitivity reaction / MGI
- abnormal hippocampus pyramidal cell layer / MGI
- decreased gamma-delta T cell number / MGI
- increased IgG2a level / MGI
- increased tumor necrosis factor secretion / MGI
- decreased interferon-gamma secretion / MGI
- abnormal interleukin secretion / MGI
- decreased interleukin-2 secretion / MGI
- abnormal interleukin-4 secretion / MGI
- increased interleukin-5 secretion / MGI
- abnormal chemokine level / MGI
- enhanced behavioral response to alcohol / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- abnormal hippocampus pyramidal cell morphology / MGI
- increased hippocampus pyramidal cell number / MGI
- ectopic hippocampus pyramidal cells / MGI
- increased serotonin level / MGI
- abnormal NK cell physiology / MGI
- abnormal Sertoli cell barrier morphology / MGI
- prolonged circadian behavior period / MGI
- abnormal locomotor circadian rhythm / MGI