C57BL/6NCrl-Lig4em1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:15733
Citation informationRRID:IMSR_EM:15733 

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International strain nameC57BL/6NCrl-Lig4em1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolLig4em1(IMPC)Ccpcz
Gene/Transgene symbolLig4

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • decreased bone marrow cell number / MGI
  • decreased cell proliferation / MGI
  • abnormal immune system morphology / MGI
  • small spleen / MGI
  • abnormal thymus morphology / MGI
  • small thymus / MGI
  • decreased thymocyte number / MGI
  • abnormal immune system cell morphology / MGI
  • abnormal lymphocyte cell number / MGI
  • absent CD8-positive, alpha-beta T cells / MGI
  • abnormal diencephalon morphology / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • postnatal growth retardation / MGI
  • abnormal immune system physiology / MGI
  • arrested B cell differentiation / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • decreased IgA level / MGI
  • arrested T cell differentiation / MGI
  • abnormal T cell activation / MGI
  • intestinal inflammation / MGI
  • liver inflammation / MGI
  • reduced fertility / MGI
  • increased cellular sensitivity to gamma-irradiation / MGI
  • increased T cell derived lymphoma incidence / MGI
  • premature death / MGI
  • abnormal B cell differentiation / MGI
  • abnormal T cell differentiation / MGI
  • abnormal lymphopoiesis / MGI
  • abnormal proerythroblast morphology / MGI
  • decreased immunoglobulin level / MGI
  • abnormal immune system organ morphology / MGI
  • increased neuron apoptosis / MGI
  • chromosome breakage / MGI
  • spontaneous chromosome breakage / MGI
  • induced chromosome breakage / MGI
  • abnormal striatum morphology / MGI
  • decreased fetal size / MGI
  • increased cellular sensitivity to ionizing radiation / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • decreased hematopoietic stem cell number / MGI
  • increased anti-chromatin antibody level / MGI
  • abnormal regulatory T cell morphology / MGI
  • decreased spleen weight / MGI
  • decreased thymus weight / MGI
  • decreased lymphocyte cell number / MGI
  • decreased B cell number / MGI
  • decreased double-negative T cell number / MGI
  • decreased double-positive T cell number / MGI
  • decreased T cell proliferation / MGI
  • abnormal brainstem morphology / MGI
  • cellular phenotype / MGI
  • hematopoietic system phenotype / MGI
  • abnormal cell physiology / MGI
  • thin cerebral cortex / MGI
  • increased medulloblastoma incidence / MGI
  • increased T cell apoptosis / MGI
  • abnormal DNA repair / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • abnormal B cell activation / MGI
  • decreased IgG2b level / MGI
  • decreased IgG3 level / MGI
  • decreased interferon-gamma secretion / MGI
  • decreased interleukin-13 secretion / MGI
  • abnormal T cell receptor V(D)J recombination / MGI
  • abnormal T cell receptor beta chain V(D)J recombination / MGI
  • chromosomal instability / MGI
  • increased colon adenocarcinoma incidence / MGI
  • decreased splenocyte number / MGI
  • prenatal lethality, complete penetrance / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • decreased fibroblast proliferation / MGI
  • increased forebrain apoptosis / MGI
  • increased spinal cord apoptosis / MGI

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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