C57BL/6NCrl-Alplem1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:15738
Citation informationRRID:IMSR_EM:15738 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NCrl-Alplem1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolAlplem1(IMPC)Ccpcz
Gene/Transgene symbolAlpl

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • fragile skeleton / MGI
  • decreased bone mineral density / MGI
  • abnormal parietal bone morphology / MGI
  • abnormal tooth development / MGI
  • abnormal long bone metaphysis morphology / MGI
  • decreased leukocyte cell number / MGI
  • abnormal small intestine morphology / MGI
  • abnormal spleen morphology / MGI
  • small spleen / MGI
  • weakness / MGI
  • abnormal spinal nerve morphology / MGI
  • lung hemorrhage / MGI
  • decreased body size / MGI
  • impaired coordination / MGI
  • internal hemorrhage / MGI
  • abnormal digestion / MGI
  • intracranial hemorrhage / MGI
  • apnea / MGI
  • seizures / MGI
  • abnormal tooth morphology / MGI
  • abnormal muscle morphology / MGI
  • abnormal thymus cortex morphology / MGI
  • decreased circulating alkaline phosphatase level / MGI
  • abnormal cementum morphology / MGI
  • abnormal alveolar process morphology / MGI
  • abnormal osteoblast morphology / MGI
  • increased bone resorption / MGI
  • abnormal osteoblast physiology / MGI
  • cachexia / MGI
  • decreased long bone epiphyseal plate size / MGI
  • pale spleen / MGI
  • decreased trabecular bone thickness / MGI
  • abnormal blood homeostasis / MGI
  • decreased total body fat amount / MGI
  • increased bone trabecula number / MGI
  • postnatal lethality, complete penetrance / MGI
  • abnormal tooth root development / MGI
  • decreased alkaline phosphatase activity / MGI
  • abnormal dental pulp morphology / MGI
  • decreased bone mineralization / MGI
  • delayed bone mineralization / MGI
  • thin parietal bone / MGI
  • abnormal dentin mineralization / MGI
  • abnormal cementum mineralization / MGI
  • abnormal odontoblast morphology / MGI
  • abnormal tooth root morphology / MGI
  • short tooth root / MGI
  • abnormal acellular cementum morphology / MGI
  • abnormal cellular cementum morphology / MGI

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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