Nlrp3_c.2750 G>A
| Status | Available to order |
| EMMA ID | EM:15753 |
| Citation information | RRID:IMSR_EM:15753 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | Nlrp3_c.2750 G>A |
| Alternative name | Nlrp3_c.2750 G>A |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Nlrp3 |
| Gene/Transgene symbol | NLR family, pyrin domain containing 3 |
Information from provider
| Provider | Silvia Murillo Cuesta |
| Provider affiliation | Instituto de Investigaciones Biomédicas Sols- Morreale |
| Genetic information | The Nlrp3 mutant mouse strain was generated using CRISPR/Cas9 technology. It carries a point mutation in exon 7 of the Nlrp3 gene: c.2750 G>A ->p.Arg917Gln. |
| Phenotypic information | Homozygous:UnknownHeterozygous:Unknown |
| Breeding history | The mouse was generated in C57BL/6 genetic background. Less than 10 generations. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J males |
Literature references
- NLRP3 inflammasome and hearing loss: from mechanisms to therapies.;Murillo-Cuesta Silvia, Seoane Elena, Cervantes Blanca, Zubeldia Jose Manuel, Varela-Nieto Isabel, ;2025;Journal of neuroinflammation;22;225; 41046290