IMPC phenotypes (gene matching)
- short tibia / IMPC
STOCK Mmp9tm1c(EUCOMM)Wtsi/IcsOrl
| Status | Available to order |
| EMMA ID | EM:15844 |
| Citation information | RRID:IMSR_EM:15844 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Mmp9tm1c(EUCOMM)Wtsi/IcsOrl |
| Alternative name | STOCK Mmp9 tm1c(EUCOMM)Wtsi/IcsOrl |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Mmp9tm1c(EUCOMM)Wtsi |
| Gene/Transgene symbol | Mmp9 |
Information from provider
| Provider | Cécile FREMOND |
| Provider affiliation | CNRS-TAAM |
| Genetic information | The original mouse line originates from EUCOMM ES clone EPD0844_5_F12. For further details on the construction of this clone see the page at ahref=http://www.knockoutmouse.org/martsearch/ikmc_project/86642the IKMC portal/a. Mice have been crossed with C57BL/6NTac-Gt(ROSA)26Sorsuptm2(CAG-flpo,-EYFP)Ics/sup/Ics to obtain the tm1c allele. |
| Phenotypic information | Homozygous:Homozygous mice have not been generatedHeterozygous:No phenotype observed. |
| Breeding history | STOCK Mmp9tm1a(EUCOMM)Wtsi/IcsOrl (EMMA strain ID EM:09960) rederived mice have been crossed with C57BL/6NTac-Gt(ROSA)26Sortm2(CAG-flpo,-EYFP)Ics/Ics (EMMA strain ID EM:05490) to obtain the tm1c allele. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6NTac males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Metaphyseal anadysplasia / Orphanet_1040
MGI phenotypes (gene matching)
- delayed bone ossification / MGI
- osteopetrosis / MGI
- abnormal trabecular bone morphology / MGI
- abnormal long bone hypertrophic chondrocyte zone / MGI
- increased monocyte cell number / MGI
- abnormal megakaryocyte differentiation / MGI
- abnormal angiogenesis / MGI
- altered response to myocardial infarction / MGI
- abnormal myelination / MGI
- increased body weight / MGI
- decreased metastatic potential / MGI
- reduced long term potentiation / MGI
- impaired myelopoiesis / MGI
- impaired hematopoiesis / MGI
- myocarditis / MGI
- lung inflammation / MGI
- decreased inflammatory response / MGI
- reduced fertility / MGI
- decreased litter size / MGI
- decreased tumor incidence / MGI
- abnormal dendritic cell physiology / MGI
- decreased susceptibility to viral infection / MGI
- decreased susceptibility to bacterial infection / MGI
- increased susceptibility to viral infection / MGI
- abnormal neutrophil physiology / MGI
- decreased IgE level / MGI
- increased IgE level / MGI
- short tibia / MGI
- increased susceptibility to dystrophic cardiac calcinosis / MGI
- delayed wound healing / MGI
- joint inflammation / MGI
- joint swelling / MGI
- thick ventricular wall / MGI
- abnormal cytokine secretion / MGI
- decreased myocardial infarction size / MGI
- hypoalgesia / MGI
- abnormal long bone epiphyseal plate morphology / MGI
- increased vascular permeability / MGI
- abnormal metatarsal bone morphology / MGI
- short femur / MGI
- abnormal impulse conducting system conduction / MGI
- cardiac fibrosis / MGI
- decreased neuron apoptosis / MGI
- increased width of hypertrophic chondrocyte zone / MGI
- decreased susceptibility to induced arthritis / MGI
- abnormal tumor morphology / MGI
- abnormal intestinal goblet cell morphology / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- abnormal physiological neovascularization / MGI
- abnormal myocardial fiber physiology / MGI
- decreased length of long bones / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- abnormal hematopoietic stem cell morphology / MGI
- abnormal vascular wound healing / MGI
- increased eosinophil cell number / MGI
- increased lymphocyte cell number / MGI
- abnormal response to infection / MGI
- decreased cardiac muscle contractility / MGI
- decreased susceptibility to injury / MGI
- abnormal blood-brain barrier function / MGI
- increased T cell proliferation / MGI
- abnormal Langerhans cell physiology / MGI
- immune system phenotype / MGI
- increased macrophage cell number / MGI
- abnormal vascular smooth muscle physiology / MGI
- increased ventricle muscle contractility / MGI
- increased angiogenesis / MGI
- increased susceptibility to type IV hypersensitivity reaction / MGI
- decreased susceptibility to ischemic brain injury / MGI
- abnormal retinal apoptosis / MGI
- aortic aneurysm / MGI
- increased T-helper 2 cell number / MGI
- decreased dendritic cell number / MGI
- abnormal leukocyte morphology / MGI
- decreased susceptibility to induced colitis / MGI
- increased interferon-gamma secretion / MGI
- decreased interferon-gamma secretion / MGI
- increased circulating interferon-beta level / MGI
- increased circulating interferon-gamma level / MGI
- decreased circulating interleukin-10 level / MGI
- increased interleukin-13 secretion / MGI
- increased interleukin-4 secretion / MGI
- increased interleukin-5 secretion / MGI
- abnormal chemokine level / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- abnormal bone marrow cell physiology / MGI
- increased tibialis anterior weight / MGI
- impaired contextual conditioning behavior / MGI
- abnormal induced retinal neovascularization / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
- decreased susceptibility to viral infection induced morbidity/mortality / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- decreased oligodendrocyte number / MGI
- increased prostaglandin level / MGI
- thick interventricular septum / MGI
- decreased histamine level / MGI