FVB;B6-Tg(L2LMP1CAO)117Wln/H
| Status | Available to order |
| EMMA ID | EM:15851 |
| Citation information | RRID:IMSR_EM:15851 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | FVB;B6-Tg(L2LMP1CAO)117Wln/H |
| Alternative name | L2LMP1 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(L2LMP1CAO)117 |
| Gene/Transgene symbol | Tg(L2LMP1CAO)117 |
Information from provider
| Provider | Joanna Wilson |
| Provider affiliation | School of Molecular Biosciences, University of Glasgow |
| Genetic information | Transgenic mice harbouring the transgene L2LMP1CAO on the Y chromosome, line 117. |
| Phenotypic information | Homozygous:NA, the insert is on the Y chromosome.Heterozygous:Male mice (Y chromosome insert) display a skin phenotype, most noted on ear pinnae and tail. The phenotype, evident in the first few weeks of life, is progressive with age showing hyperplasia, hypervascularisation, and chronic inflammation, ears becoming thicker with age. With increasing age the ear pinnae show ulcerative dermatitis and erosion, becoming degenerative with time. Keratoacanthomas occasionally form on the ears and a a low number of small papillomas may from on the back of the head and dorsal skin. A full description can be found at Stevenson et al (2005), Cancer Res: 65:8826-8835 PMID: 16204053 |
| Breeding history | The line was generated by DNA microinjection into zygotes (B6D2 F2 background, hence Y chromosome was of strain DBA/2). The mice of this line (117) were initially backcrossed to C57BL/6 for several generations. The line was then backcrossed to FVB for multiple generations and remains in FVB, although there may be vestiges of the other strains, particularly the regions of the Y chromosome out with the pseudoautosomal regions, since to maintain the transgene, only female strain mice have been used for backcrossing. (Note, another line with similar but milder phenotype (same transgene), named L2LMP1CAO line105, with an autosomal insert, is available as frozen embryos only). |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Lymphocyte deficiency limits Epstein-Barr virus latent membrane protein 1 induced chronic inflammation and carcinogenic pathology in vivo.;Hannigan Adele, Qureshi Asif M, Nixon Colin, Tsimbouri Penelope M, Jones Sarah, Philbey Adrian W, Wilson Joanna B, ;2011;Molecular cancer;10;11; 21291541
- N-acetylcysteine (NAC) ameliorates Epstein-Barr virus latent membrane protein 1 induced chronic inflammation.;Gao Xiao, Lampraki Eirini-Maria, Al-Khalidi Sarwah, Qureshi Muhammad Asif, Desai Rhea, Wilson Joanna Beatrice, ;2017;PloS one;12;e0189167; 29228057
- Latent membrane protein 1-induced EGFR signalling is negatively regulated by TGF alpha prior to neoplasia.;Charalambous Chrystalla T, Hannigan Adele, Tsimbouri Penelope, McPhee Gordon M, Wilson Joanna B, ;2007;Carcinogenesis;28;1839-48; 17361012
- Epstein-Barr virus latent membrane protein 1 (CAO) up-regulates VEGF and TGF alpha concomitant with hyperlasia, with subsequent up-regulation of p16 and MMP9.;Stevenson David, Charalambous Chrystalla, Wilson Joanna B, ;2005;Cancer research;65;8826-35; 16204053
- Chitinase-like proteins are autoantigens in a model of inflammation-promoted incipient neoplasia.;Qureshi Asif M, Hannigan Adele, Campbell Donald, Nixon Colin, Wilson Joanna B, ;2011;Genes & cancer;2;74-87; 21779482