IMPC phenotypes (gene matching)
C57BL/6N-Tcf7l2tm2a(EUCOMM)Wtsi/WtsiH
| Status | Available to order |
| EMMA ID | EM:15863 |
| Citation information | RRID:IMSR_EM:15863 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Tcf7l2tm2a(EUCOMM)Wtsi/WtsiH |
| Alternative name | C57BL/6N-Tcf7l2 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tcf7l2tm2a(EUCOMM)Wtsi |
| Gene/Transgene symbol | Tcf7l2 |
Information from provider
| Provider | Seth Grant |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | This line was generated by The Wellcome Trust Sanger Mouse Genetics Project (Sanger MGP). This strain carries a conditional knockout of the gene Tcf7l2.Critical exons are flanked by loxP sites along witht he insertion of a L1L2_Bact_P cassette flanked by FRT sites followed by lacZ sequence and a loxP site. |
| Breeding history | Used mice from MGP line MBTQ. Maintained as Het x JAXJ (C57BL/6J). Hom lethal. The strain is currently maintained on a mixed background : C57BL/6J C57BL/6Brd-Tyrc-Brd C57BL/6N |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Non-specific syndromic intellectual disability / Orphanet_528084
MGI phenotypes (gene matching)
- hypoglycemia / MGI
- double outlet right ventricle / MGI
- decreased enterocyte cell number / MGI
- abnormal intestine morphology / MGI
- abnormal enterocyte morphology / MGI
- abnormal intestinal epithelium morphology / MGI
- abnormal crypts of Lieberkuhn morphology / MGI
- abnormal colon morphology / MGI
- abnormal small intestine morphology / MGI
- absent kidney / MGI
- enlarged liver sinusoidal spaces / MGI
- enlarged pituitary gland / MGI
- abnormal forebrain morphology / MGI
- decreased body weight / MGI
- hypoactivity / MGI
- polyphagia / MGI
- abnormal glucose homeostasis / MGI
- abnormal nasal septum morphology / MGI
- decreased circulating insulin level / MGI
- abnormal intestinal goblet cell morphology / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- abnormal eye muscle morphology / MGI
- abnormal Mullerian duct morphology / MGI
- abnormal Wolffian duct morphology / MGI
- abnormal craniofacial development / MGI
- decreased lean body mass / MGI
- retroesophageal right subclavian artery / MGI
- abnormal neurohypophysis morphology / MGI
- basisphenoid bone foramen / MGI
- vertebral fusion / MGI
- fusion of vertebral arches / MGI
- improved glucose tolerance / MGI
- impaired glucose tolerance / MGI
- homeostasis/metabolism phenotype / MGI
- cellular phenotype / MGI
- increased circulating glucose level / MGI
- decreased circulating glucose level / MGI
- abnormal inferior vena cava morphology / MGI
- abnormal pituitary intermediate lobe morphology / MGI
- enlarged adenohypophysis / MGI
- abnormal enterocyte proliferation / MGI
- absent gastric milk in neonates / MGI
- decreased birth weight / MGI
- decreased birth body size / MGI
- decreased total body fat amount / MGI
- abnormal hepatocyte physiology / MGI
- perimembraneous ventricular septal defect / MGI
- muscular ventricular septal defect / MGI
- common truncal valve / MGI
- abnormal pulmonary valve cusp morphology / MGI
- abnormal intestinal enteroendocrine cell morphology / MGI
- neonatal lethality, complete penetrance / MGI
- lethality, complete penetrance / MGI
- abnormal vertebral artery morphology / MGI
- abnormal basilar artery morphology / MGI
- embryo tissue necrosis / MGI
- abnormal small intestine goblet cell morphology / MGI
- abnormal colon goblet cell morphology / MGI
- abnormal cecum position / MGI
- absent ductus venosus valve / MGI
- duplication of ductus venosus / MGI
- abnormal ureter topology / MGI
- abnormal elbow joint morphology / MGI
- symmetric azygos veins / MGI
- abnormal umbilical vein topology / MGI
- abnormal vertebral artery topology / MGI
- heterochrony / MGI
- abnormal inferior vena cava topology / MGI