- increased total body fat amount / IMPC
- decreased bone mineral density / IMPC
- abnormal auditory brainstem response / IMPC
- decreased startle reflex / IMPC
- abnormal startle reflex / IMPC
- decreased bone mineral content / IMPC
- increased vertical activity / IMPC
- decreased lean body mass / IMPC
- decreased prepulse inhibition / IMPC
C57BL/6NTac-Clrn2em1H/H
Status | Available to order |
EMMA ID | EM:15951 |
Citation information | RRID:IMSR_EM:15951 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | C57BL/6NTac-Clrn2em1H/H |
Alternative name | C57BL/6NTac-Clrn2 |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Clrn2em1H |
Gene/Transgene symbol | Clrn2 |
Information from provider
Provider | MRC, Medical Research Council |
Provider affiliation | Mary Lyon Centre at MRC Harwell |
Genetic information | Clrn2 CRISPR/Cas9 flox project (Line 1) nominated by Mike Bowl/Lucy Dunbar. The aim of this project is to flox a critical exon using a lssDNA donor, but a null allele is also of interest. This has a 629 deletion encompassing ENSMUSE00000401986 replaced by an insertion of 5 nt together with an 8 nt at the 3' guide site. |
Phenotypic information | Homozygous mice have hearing loss |
Breeding history | Maintained on C57BL/6N |
References |
|
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | not known |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
IMPC phenotypes (gene matching)
Literature references
- Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.;Dunbar Lucy A, Patni Pranav, Aguilar Carlos, Mburu Philomena, Corns Laura, Wells Helena Rr, Delmaghani Sedigheh, Parker Andrew, Johnson Stuart, Williams Debbie, Esapa Christopher T, Simon Michelle M, Chessum Lauren, Newton Sherylanne, Dorning Joanne, Jeyarajan Prashanthini, Morse Susan, Lelli Andrea, Codner Gemma F, Peineau Thibault, Gopal Suhasini R, Alagramam Kumar N, Hertzano Ronna, Dulon Didier, Wells Sara, Williams Frances M, Petit Christine, Dawson Sally J, Brown Steve Dm, Marcotti Walter, El-Amraoui Aziz, Bowl Michael R, ;2019;EMBO molecular medicine;11;e10288; 31448880
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