FVB-Tg(Myh6-ITGB1BP2)3Mbra/Cnrm

Status	Under development - register interest
EMMA ID	EM:15968
Citation information	RRID:IMSR_EM:15968 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	FVB-Tg(Myh6-ITGB1BP2)3Mbra/Cnrm
Alternative name	ITGB1BP2 Tg (Melusin Tg)
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Myh6-ITGB1BP2)3Mbra
Gene/Transgene symbol	Tg(Myh6-ITGB1BP2)3Mbra

Information from provider

Provider	Mara Brancaccio
Provider affiliation	Department of Molecular Biotechnology and Health Sciences, University of Torino
Genetic information	Alpha-MHC promoter was cloned upstream the Myc-tagged human melusin (integrin beta 1 binding protein 2, ITGB1BP2) cDNA followed by beta-globin intron and poly-A. The DNA construct was microinjected in FVB fertilized eggs and transgenic integration was confirmed by Southern blot.
Phenotypic information	Homozygous: Mice overexpressing melusin in the heart exhibited prolonged concentric compensatory hypertrophy and were protected against the transition to cardiac dilation and failure in response to long-standing pressure overload. Heterozygous: We used mainly homozygous mice for phenotype studies.
Breeding history	Heterozygous mice were bred to produce homozygous offspring carrying the construct on both alleles.
References	Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction.;Unsöld Bernhard, Kaul Axel, Sbroggiò Mauro, Schubert Carola, Regitz-Zagrosek Vera, Brancaccio Mara, Damilano Federico, Hirsch Emilio, Van Bilsen Marc, Munts Chantal, Sipido Karin, Bito Virginie, Detre Elke, Wagner Nana Maria, Schäfer Katrin, Seidler Tim, Vogt Johannes, Neef Stefan, Bleckmann Annalen, Maier Lars S, Balligand Jean Luc, Bouzin Caroline, Ventura-Clapier Renée, Garnier Anne, Eschenhagen Thomas, El-Armouche Ali, Knöll Ralph, Tarone Guido, Hasenfuß Gerd, ;2014;Cardiovascular research;101;97-107; 24130190 Overexpression of the muscle-specific protein, melusin, protects from cardiac ischemia/reperfusion injury.;Penna Claudia, Brancaccio Mara, Tullio Francesca, Rubinetto Cristina, Perrelli Maria-Giulia, Angotti Carmelina, Pagliaro Pasquale, Tarone Guido, ;2014;Basic research in cardiology;109;418; 24859929 Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload.;De Acetis Marika, Notte Antonella, Accornero Federica, Selvetella Giulio, Brancaccio Mara, Vecchione Carmine, Sbroggiò Mauro, Collino Federica, Pacchioni Beniamina, Lanfranchi Gerolamo, Aretini Alessandra, Ferretti Roberta, Maffei Angelo, Altruda Fiorella, Silengo Lorenzo, Tarone Guido, Lembo Giuseppe, ;2005;Circulation research;96;1087-94; 15860758
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Literature references

Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction.;Unsöld Bernhard, Kaul Axel, Sbroggiò Mauro, Schubert Carola, Regitz-Zagrosek Vera, Brancaccio Mara, Damilano Federico, Hirsch Emilio, Van Bilsen Marc, Munts Chantal, Sipido Karin, Bito Virginie, Detre Elke, Wagner Nana Maria, Schäfer Katrin, Seidler Tim, Vogt Johannes, Neef Stefan, Bleckmann Annalen, Maier Lars S, Balligand Jean Luc, Bouzin Caroline, Ventura-Clapier Renée, Garnier Anne, Eschenhagen Thomas, El-Armouche Ali, Knöll Ralph, Tarone Guido, Hasenfuß Gerd, ;2014;Cardiovascular research;101;97-107; 24130190
Overexpression of the muscle-specific protein, melusin, protects from cardiac ischemia/reperfusion injury.;Penna Claudia, Brancaccio Mara, Tullio Francesca, Rubinetto Cristina, Perrelli Maria-Giulia, Angotti Carmelina, Pagliaro Pasquale, Tarone Guido, ;2014;Basic research in cardiology;109;418; 24859929
Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload.;De Acetis Marika, Notte Antonella, Accornero Federica, Selvetella Giulio, Brancaccio Mara, Vecchione Carmine, Sbroggiò Mauro, Collino Federica, Pacchioni Beniamina, Lanfranchi Gerolamo, Aretini Alessandra, Ferretti Roberta, Maffei Angelo, Altruda Fiorella, Silengo Lorenzo, Tarone Guido, Lembo Giuseppe, ;2005;Circulation research;96;1087-94; 15860758

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