IMPC phenotypes (gene matching)
- preweaning lethality, complete penetrance / IMPC
Jag2emMaros
| Status | Available to order |
| EMMA ID | EM:15989 |
| Citation information | RRID:IMSR_EM:15989 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | Jag2emMaros |
| Alternative name | Jag2emMaros |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Jag2emMaros |
| Gene/Transgene symbol | Jag2 |
Information from provider
| Provider | Marian Ros |
| Provider affiliation | CSIC-IBBTEC |
| Genetic information | Loss of function deletion of 41 nucleotides in exon 4 of jagged 2 gene. The Cas9 protein used in our experiments is: Alt-R® S.p. HiFi Cas9 Nuclease V3 (Ref. 1081060). |
| Phenotypic information | Homozygous:Soft tissue syndactyly of digits 2 to 4. Homozygous Jag2 mutants die at birth with cleft palate of the secondary palate. This is a complete loss of function mutation which faithfully recapitulates the previously published loss of function phenotype (Jiang et al. 1998; PubMed ID 9531541). Heterozygous:Wild-type |
| Breeding history | Since 2022 on C57BL/6 background. |
| References | None available |
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6JHsd males |
Disease and phenotype information
MGI phenotypes (gene matching)
- cleft palate / MGI
- absent maxillary shelf / MGI
- absent palatine bone horizontal plate / MGI
- syndactyly / MGI
- abnormal autopod morphology / MGI
- kinked tail / MGI
- abnormal thymus morphology / MGI
- epidermal hyperplasia / MGI
- cyanosis / MGI
- abnormal apical ectodermal ridge morphology / MGI
- thick apical ectodermal ridge / MGI
- female infertility / MGI
- respiratory distress / MGI
- abnormal tail morphology / MGI
- abnormal thymus medulla morphology / MGI
- abnormal caudal vertebrae morphology / MGI
- no phenotypic analysis / MGI
- parakeratosis / MGI
- increased cochlear inner hair cell number / MGI
- abnormal cochlear outer hair cell morphology / MGI
- increased cochlear outer hair cell number / MGI
- increased cochlear hair cell number / MGI
- abnormal orientation of inner hair cell stereociliary bundles / MGI
- decreased organ of Corti supporting cell number / MGI
- abnormal orientation of cochlear hair cell stereociliary bundles / MGI
- abnormal embryonic autopod plate morphology / MGI
- abnormal phalanx morphology / MGI
- abnormal limb bud morphology / MGI
- abnormal digit development / MGI
- decreased gamma-delta T cell number / MGI
- abnormal gamma-delta T cell differentiation / MGI
- fused phalanges / MGI
- fused tarsal bones / MGI
- palatal shelf fusion with tongue or mandible / MGI
- failure of palatal shelf elevation / MGI
- cleft secondary palate / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI