Ankrd11tm1c(EUCOMM)Wtsi/Ics

Status

Available to order

EMMA IDEM:16058
Citation informationRRID:IMSR_EM:16058 

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International strain nameAnkrd11tm1c(EUCOMM)Wtsi/Ics
Alternative nameAnkrd11tm1c(EUCOMM)Wtsi/Ics
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolAnkrd11tm1c(EUCOMM)Wtsi
Gene/Transgene symbolAnkrd11

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic information"Conditional ready" (floxed) allele obtained from the line STOCK Ankrd11tm1a(EUCOMM)Wtsi/IcsOrl (EMMA strain EM:07651). The L1L2_Bact_P cassette was removed by flp-mediated recombination using a flpo deleter mouse line (MGI:5285396).
Phenotypic informationHomozygous:
N/A

Heterozygous:
N/A
Breeding historyLine produced in C57BL/6N genetic background, 6 breedings steps, one with a CamKIIa-cre line with little C57BL/6J genetic background. Current background: C57BL/6J 1.5625%, C57BL/6N 98.4375%
References
  • Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.;Meziane Hamid, Birling Marie-Christine, Wendling Olivia, Leblanc Sophie, Dubos Aline, Selloum Mohammed, Pavlovic Guillaume, Sorg Tania, Kalscheuer Vera M, Billuart Pierre, Laumonnier Frédéric, Chelly Jamel, van Bokhoven Hans, Herault Yann, ;2022;Biomedicines;10;; 36551904
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased bone mineral density / IMPC
  • decreased startle reflex / IMPC
  • abnormal retina vasculature morphology / IMPC
  • decreased lean body mass / IMPC
  • increased circulating cholesterol level / IMPC
  • increased total body fat amount / IMPC
  • abnormal vitreous body morphology / IMPC
  • abnormal response to new environment / IMPC
  • decreased heart weight / IMPC
  • abnormal auditory brainstem response / IMPC
  • abnormal head morphology / IMPC
  • abnormal startle reflex / IMPC
  • increased bone mineral content / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • decreased prepulse inhibition / IMPC
  • decreased body length / IMPC
  • abnormal embryo development / IMPC
  • increased circulating HDL cholesterol level / IMPC
MGI phenotypes (gene matching)
  • decreased bone mineral density / MGI
  • abnormal nasal bone morphology / MGI
  • kyphosis / MGI
  • domed cranium / MGI
  • increased cranium width / MGI
  • decreased body length / MGI
  • decreased body weight / MGI
  • decreased embryo size / MGI
  • abnormal craniofacial bone morphology / MGI
  • abnormal bone structure / MGI
  • abnormal metopic suture morphology / MGI
  • decreased bone mass / MGI
  • failure of initiation of embryo turning / MGI
  • short frontal bone / MGI
  • enlarged parietal bone / MGI
  • short nasal bone / MGI
  • decreased osteoclast cell number / MGI
  • decreased circulating leptin level / MGI
  • abnormal frontonasal suture morphology / MGI
  • decreased compact bone area / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • short face / MGI
  • broad face / MGI

Literature references

  • Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.;Meziane Hamid, Birling Marie-Christine, Wendling Olivia, Leblanc Sophie, Dubos Aline, Selloum Mohammed, Pavlovic Guillaume, Sorg Tania, Kalscheuer Vera M, Billuart Pierre, Laumonnier Frédéric, Chelly Jamel, van Bokhoven Hans, Herault Yann, ;2022;Biomedicines;10;; 36551904

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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