Ascc3tm1c(EUCOMM)Hmgu/Ics

Status	Available to order
EMMA ID	EM:16060
Citation information	RRID:IMSR_EM:16060 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	Ascc3tm1c(EUCOMM)Hmgu/Ics
Alternative name	Ascc3tm1c(EUCOMM)Hmgu/Ics
Strain type	Targeted Mutant Strains : Conditional mutation
Allele/Transgene symbol	Ascc3^{tm1c(EUCOMM)Hmgu}
Gene/Transgene symbol	Ascc3

Information from provider

Provider	ICS, Institut Clinique de la Souris
Provider affiliation	ICS, Institut Clinique de la Souris
Genetic information	"Condition ready" (floxed) allele obtained from the line C57BL/6NTac-Ascc3^{tm1a(EUCOMM)Hmgu}/IcsOrl (EMMA strain EM:07647). The L1L2_Bact_P cassette was removed by flp-mediated recombination using a flpo deleter mouse line (MGI:5285396).
Phenotypic information	Homozygous: N/A Heterozygous: N/A
Breeding history	Line backcrossed in C57BL/6NTac. Current background: C57BL/6N 2.1484%, C57BL/6NTac 97.8516%
References	Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.;Meziane Hamid, Birling Marie-Christine, Wendling Olivia, Leblanc Sophie, Dubos Aline, Selloum Mohammed, Pavlovic Guillaume, Sorg Tania, Kalscheuer Vera M, Billuart Pierre, Laumonnier Frédéric, Chelly Jamel, van Bokhoven Hans, Herault Yann, ;2022;Biomedicines;10;; 36551904
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

IMPC phenotypes (gene matching)

preweaning lethality, complete penetrance / IMPC
abnormal retina morphology / IMPC
long tibia / IMPC
increased lean body mass / IMPC
increased total body fat amount / IMPC
increased startle reflex / IMPC

Literature references

Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.;Meziane Hamid, Birling Marie-Christine, Wendling Olivia, Leblanc Sophie, Dubos Aline, Selloum Mohammed, Pavlovic Guillaume, Sorg Tania, Kalscheuer Vera M, Billuart Pierre, Laumonnier Frédéric, Chelly Jamel, van Bokhoven Hans, Herault Yann, ;2022;Biomedicines;10;; 36551904

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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