Cdk8tm1c(EUCOMM)Hmgu/Ics

Status	Available to order
EMMA ID	EM:16062
Citation information	RRID:IMSR_EM:16062 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	Cdk8tm1c(EUCOMM)Hmgu/Ics
Alternative name	Cdk8tm1c(EUCOMM)Hmgu/Ics
Strain type	Targeted Mutant Strains : Conditional mutation
Allele/Transgene symbol	Cdk8^{tm1c(EUCOMM)Hmgu}
Gene/Transgene symbol	Cdk8

Information from provider

Provider	ICS, Institut Clinique de la Souris
Provider affiliation	ICS, Institut Clinique de la Souris
Genetic information	"Condition ready" (floxed) allele obtained from the line STOCK Cdk8^{tm1a(EUCOMM)Hmgu}/IcsOrl (EMMA strain EM:07633). The L1L2_Bact_P cassette was removed by flp-mediated recombination using a flpo deleter mouse line (MGI:5285396).
Phenotypic information	Homozygous: N/A Heterozygous: N/A
Breeding history	Line backcrossed in C57BL/6NTac. Current background: C57BL/6J 3.1250%, C57BL/6N 2.1484%, C57BL/6NTac 94.7266%
References	CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells.;Xue Jing, Scotti Elena, Stoffel Markus, ;2019;Cell reports;28;2892-2904.e7; 31509750
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

IMPC phenotypes (gene matching)

preweaning lethality, complete penetrance / IMPC
abnormal embryo size / IMPC
abnormal heart morphology / IMPC
abnormal neural tube closure / IMPC
decreased exploration in new environment / IMPC
abnormal freezing behavior / IMPC
abnormal embryo turning / IMPC

MGI phenotypes (gene matching)

abnormal preimplantation embryo development / MGI
embryonic lethality before implantation, complete penetrance / MGI
failure of morula compaction / MGI

Literature references

CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells.;Xue Jing, Scotti Elena, Stoffel Markus, ;2019;Cell reports;28;2892-2904.e7; 31509750

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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