Tti2tm1c(KOMP)Wtsi/Ics

Status	Available to order
EMMA ID	EM:16077
Citation information	RRID:IMSR_EM:16077 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	Tti2tm1c(KOMP)Wtsi/Ics
Alternative name	Tti2tm1c(KOMP)Wtsi/Ics
Strain type	Targeted Mutant Strains : Conditional mutation
Allele/Transgene symbol	Tti2^{tm1c(KOMP)Wtsi}
Gene/Transgene symbol	Tti2

Information from provider

Provider	ICS, Institut Clinique de la Souris
Provider affiliation	ICS, Institut Clinique de la Souris
Genetic information	"Condition ready" (floxed) allele obtained from the line B6NCrl;B6N-A^tm1Brd Tti2^{tm1a(KOMP)Wtsi}/Icsl (EMMA strain EM:10604). The L1L2_Bact_P cassette was removed by flp-mediated recombination using a flpo deleter mouse line (MGI:5285396).
Phenotypic information	Homozygous: N/A Heterozygous: N/A
Breeding history	Pure C57BL/6N genetic background. Current background: C57BL/6N 0.0548%, C57BL/6NCrl 86.7188%, C57BL/6NTac 13.2264%
References	Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.;Meziane Hamid, Birling Marie-Christine, Wendling Olivia, Leblanc Sophie, Dubos Aline, Selloum Mohammed, Pavlovic Guillaume, Sorg Tania, Kalscheuer Vera M, Billuart Pierre, Laumonnier Frédéric, Chelly Jamel, van Bokhoven Hans, Herault Yann, ;2022;Biomedicines;10;; 36551904
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Severe intellectual disability-short stature-behavioral abnormalities-facial dysmorphism syndrome / Orphanet_391307

IMPC phenotypes (gene matching)

increased neutrophil cell number / IMPC
decreased lymphocyte cell number / IMPC
decreased exploration in new environment / IMPC
preweaning lethality, complete penetrance / IMPC

Literature references

Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.;Meziane Hamid, Birling Marie-Christine, Wendling Olivia, Leblanc Sophie, Dubos Aline, Selloum Mohammed, Pavlovic Guillaume, Sorg Tania, Kalscheuer Vera M, Billuart Pierre, Laumonnier Frédéric, Chelly Jamel, van Bokhoven Hans, Herault Yann, ;2022;Biomedicines;10;; 36551904

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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