129S9/SvEv-Camk2aem1H/H
| Status | Available to order |
| EMMA ID | EM:16096 |
| Citation information | RRID:IMSR_EM:16096 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129S9/SvEv-Camk2aem1H/H |
| Alternative name | 129S9/SvEv-Camk2a |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Camk2aem1H |
| Gene/Transgene symbol | Camk2a |
Information from provider
| Provider | Mary Lyon Centre at MRC Harwell |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | Camk2a, a subunit of holoenzyme Camk2, Is expressed primarily in glutamatergic neurons of the forebrain. Autophosphorylation of T286 in Cmk2a has previously been associated with spatial memory formation as well as induction of NMDA receptor dependant long term potentiation. This strain carries a a CRISPR/Cas9 induced mutation creating a series of point mutations; T286P in exon ENSMUSE00000572373 of CAMK2A and can be useful in studying the role of Camk2a as well as T286 phosphorylation in synaptic plasticity and neuronal circuit formation. |
| Phenotypic information | Homozygous:No phenotype data available. Seizure like behavious observed on B6J background and the strain was threrefore crossed and maintained on 129. However, further welfare checks may be required.Heterozygous:No phenotype data available. |
| Breeding history | Originated on C57BL/6J. Currently maintained on 129S9/SvEv |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal dominant non-syndromic intellectual disability / Orphanet_178469