IMPC phenotypes (gene matching)
C57BL/6NTac-Acvr2bem2H/H
| Status | Available to order |
| EMMA ID | EM:16098 |
| Citation information | RRID:IMSR_EM:16098 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NTac-Acvr2bem2H/H |
| Alternative name | C57BL/6NTac-Acvr2b |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Acvr2bem2H |
| Gene/Transgene symbol | Acvr2b |
Information from provider
| Provider | Mary Lyon Centre at MRC Harwell |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | Activin A and Acivin receptor subunits including Acvr2b play a role in the remyelination of Oligodendrocyte progenitor cells, a process shown to be hampered in the pathogenesis of Multiple Sclerosis. This strain carries floxed critical exons for Acvr2b and can be useful for studying molecular mechanisms involved in remyelination. |
| Phenotypic information | Homozygous:no data availableHeterozygous:no data available |
| Breeding history | Coisogenic on C57BL/6NTac |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |