C57BL/6NCrl-Dyrk1aem2Ics/Ics
| Status | Available to order |
| EMMA ID | EM:16181 |
| Citation information | RRID:IMSR_EM:16181 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NCrl-Dyrk1aem2Ics/Ics |
| Alternative name | Dyrk1aem2Ics/Ics |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Dyrk1aem2Ics |
| Gene/Transgene symbol | Dyrk1a |
Information from provider
| Provider | Yann Herault |
| Provider affiliation | ICS, IGBMC |
| Genetic information | The lysine codon 188 (AAA) in exon 6 was changed to arginine (AGA) (p.K188R) and a loxP site, a neomycin resistance gene cassette, an FRT site-flanked auto-excision protamine-cre cassette and a second loxP site were inserted into intron 6 using a crRNA (equivalent to AATGTGGCCTGGCTATAAT) with CRISPR/Cas9 technology. The mutation renders the encoded protein kinase-dead, which affects cortical interneuron development. |
| Phenotypic information | Homozygous:N/AHeterozygous:N/A |
| Breeding history | C57BL/6NCrl 100% |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Literature references
- Interneuron migration defects during corticogenesis contribute to Dyrk1a haploinsufficiency syndrome pathogenesis.;Hinckelmann Maria Victoria, Dubos Aline, Artot Victorine, Rudolf Gabrielle, Nguyen Thu Lan, Tilly Peggy, Nalesso Valérie, Muniz Moreno Maria Del Mar, Birling Marie-Christine, Godin Juliette D, Brault Véronique, Herault Yann, ;2025;Molecular psychiatry;30;5227-5244; 40634533