Tlr7tm1.1(EYFP/cre)Ics/Ics

Status	Available to order
EMMA ID	EM:16201
Citation information	RRID:IMSR_EM:16201 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	Tlr7tm1.1(EYFP/cre)Ics/Ics
Alternative name	Tlr7tm1.1(EYFP/cre)Ics/Ics
Strain type	Targeted Mutant Strains : Knock-in
Allele/Transgene symbol	Tlr7^{tm1.1(EYFP/cre)Ics}
Gene/Transgene symbol	Tlr7

Information from provider

Provider	Jean-Charles Guéry
Provider affiliation	Hôpital Purpan, INFINITY - Institut Toulousain des Maladies Infectieuses et Inflammatoires, CHU de Toulouse
Genetic information	IRES sequence plus EYFP reporter and cre recombinase gene chimeric coding sequence were inserted after the stop codon in exon 3 (ENSMUSE00000690633), and an FRT site flanked neomycin resistance gene cassette site was inserted downstream of the gene. The neo cassette was removed through subsequent flp-mediated recombination.
Phenotypic information	Homozygous: N/A Heterozygous: N/A
Breeding history	C57BL/6NCrl 99,98% C57BL/6NTac 0.01%
References	None available
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

MGI phenotypes (gene matching)

decreased IgG level / MGI
decreased IgM level / MGI
abnormal dendritic cell physiology / MGI
abnormal macrophage physiology / MGI
decreased anti-insulin autoantibody level / MGI
hematopoietic system phenotype / MGI
decreased follicular B cell number / MGI
increased marginal zone B cell number / MGI
decreased IgG1 level / MGI
decreased IgG2a level / MGI
decreased tumor necrosis factor secretion / MGI
decreased circulating interferon-alpha level / MGI
decreased interleukin-12b secretion / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.
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