IMPC phenotypes (gene matching)
Bmp10tm3c(EUCOMM)Hmgu/ICS
| Status | Available to order |
| EMMA ID | EM:16208 |
| Citation information | RRID:IMSR_EM:16208 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | Bmp10tm3c(EUCOMM)Hmgu/ICS |
| Alternative name | Bmp10tm3c(EUCOMM)Hmgu/ICS |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Bmp10tm3c(EUCOMM)Hmgu |
| Gene/Transgene symbol | Bmp10 |
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | We used EUCOMM Es clone : HEPD0651_3_D08 LoxP sites flank exon 2. The L1L2_Bact_P cassette was inserted at position 87433089 of Chromosome 6 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 87434716. The critical exon(s) is/are thus flanked by loxP sites. Flp-mediated recombination removed the lacZ sequence and the selection cassette leading to a conditional-ready allele. |
| Phenotypic information | Homozygous:N/AHeterozygous:N/A |
| Breeding history | 100% C57BL/6N (C57BL/6N 0,05% C57BL/6NCrl 71,10% C57BL/6NTac 28,85%) |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal vascular development / MGI
- abnormal heart morphology / MGI
- abnormal heart development / MGI
- enlarged heart / MGI
- abnormal heart shape / MGI
- ventricular hypoplasia / MGI
- thin ventricular wall / MGI
- double outlet right ventricle / MGI
- enlarged pericardium / MGI
- trabecula carnea hypoplasia / MGI
- absent atrioventricular cushions / MGI
- decreased embryo size / MGI
- absent vitelline blood vessels / MGI
- embryonic growth arrest / MGI
- pericardial edema / MGI
- thymus hypoplasia / MGI
- hemorrhage / MGI
- no abnormal phenotype detected / MGI
- hydrops fetalis / MGI
- heart hypoplasia / MGI
- curly tail / MGI
- dilated dorsal aorta / MGI
- abnormal vitelline vascular remodeling / MGI
- abnormal cardinal vein morphology / MGI
- decreased heart rate / MGI
- embryo phenotype / MGI
- cardiovascular system phenotype / MGI
- arteriovenous malformation / MGI
- polycystic kidney / MGI
- petechiae / MGI
- ventricular septal defect / MGI
- subarterial ventricular septal defect / MGI
- pulmonary artery hypoplasia / MGI
- absent conotruncal ridges / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- decreased fetal cardiomyocyte proliferation / MGI
Literature references
- BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer.;Ouarné M, Bouvard C, Boneva G, Mallet C, Ribeiro J, Desroches-Castan A, Soleilhac E, Tillet E, Peyruchaud O, Bailly S.;2018;J Exp Clin Cancer Res;37;209; 30165893