C57BL/6N-Tmprss6^{tm1b(EUCOMM)Wtsi}/Ics

Status	Available to order
EMMA ID	EM:16228
Citation information	RRID:IMSR_EM:16228 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6N-Tmprss6^{tm1b(EUCOMM)Wtsi}/Ics
Alternative name	Tmprss6tm1b(EUCOMM)Wtsi/Ics
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Tmprss6^{tm1b(EUCOMM)Wtsi}
Gene/Transgene symbol	Tmprss6

Information from provider

Provider	ICS, Institut Clinique de la Souris
Provider affiliation	ICS, Institut Clinique de la Souris
Genetic information	The cre-mediated excision of the parental Tmprss6^{tm1a(EUCOMM)Wtsi} allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence.
Phenotypic information	Homozygous: N/A Heterozygous: N/A
Breeding history	100% C57BL/6N (C57BL/6NCrl 74,61% C57BL/6NTac 25,39%)
References	None available
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IRIDA syndrome / Orphanet_209981

IMPC phenotypes (allele matching)

increased circulating calcium level / IMPC
decreased hematocrit / IMPC
abnormal coat/ hair morphology / IMPC
decreased locomotor activity / IMPC
decreased exploration in new environment / IMPC
abnormal coat appearance / IMPC
abnormal skin morphology / IMPC
abnormal coat/hair pigmentation / IMPC
decreased mean corpuscular volume / IMPC
short tibia / IMPC
increased heart weight / IMPC
decreased hemoglobin content / IMPC
immune system phenotype / IMPC
decreased mean corpuscular hemoglobin / IMPC
decreased mean corpuscular hemoglobin concentration / IMPC
decreased NK cell number / IMPC
decreased CD8-positive, alpha-beta T cell number / IMPC
decreased prepulse inhibition / IMPC
increased effector memory CD8-positive, alpha-beta T cell number / IMPC
increased fasting circulating glucose level / IMPC
increased CD11b-high dendritic cell number / IMPC
increased Ly6C-positive mature NK cell number / IMPC

IMPC phenotypes (gene matching)

short tibia / IMPC
decreased prepulse inhibition / IMPC
decreased mean corpuscular hemoglobin concentration / IMPC
abnormal coat/ hair morphology / IMPC
abnormal coat/hair pigmentation / IMPC
decreased exploration in new environment / IMPC
abnormal skin morphology / IMPC
decreased locomotor activity / IMPC
increased heart weight / IMPC
increased fasting circulating glucose level / IMPC
abnormal coat appearance / IMPC
increased Ly6C-positive mature NK cell number / IMPC
decreased NK cell number / IMPC
increased circulating calcium level / IMPC
decreased mean corpuscular hemoglobin / IMPC
increased CD11b-high dendritic cell number / IMPC
decreased mean corpuscular volume / IMPC
decreased hemoglobin content / IMPC
increased effector memory CD8-positive, alpha-beta T cell number / IMPC
immune system phenotype / IMPC
decreased CD8-positive, alpha-beta T cell number / IMPC
decreased hematocrit / IMPC

MGI phenotypes (gene matching)

decreased hematocrit / MGI
extramedullary hematopoiesis / MGI
abnormal hair follicle morphology / MGI
alopecia / MGI
sparse hair / MGI
focal hair loss / MGI
decreased body size / MGI
anemia / MGI
abnormal intestinal mineral absorption / MGI
postnatal growth retardation / MGI
abnormal iron level / MGI
reduced female fertility / MGI
female infertility / MGI
abnormal erythrocyte morphology / MGI
decreased mean corpuscular volume / MGI
reticulocytosis / MGI
anisopoikilocytosis / MGI
microcytic anemia / MGI
microcytosis / MGI
decreased hemoglobin content / MGI
decreased erythrocyte cell number / MGI
abnormal ovary development / MGI
pallor / MGI
maternal effect / MGI
decreased circulating iron level / MGI
increased spleen weight / MGI
hematopoietic system phenotype / MGI
decreased mean corpuscular hemoglobin / MGI
abnormal iron homeostasis / MGI
decreased mean corpuscular hemoglobin concentration / MGI
decreased liver iron level / MGI
decreased spleen iron level / MGI
progressive hair loss / MGI
increased red blood cell distribution width / MGI
abnormal hair follicle infundibulum morphology / MGI
thin hair follicle outer root sheath / MGI
mortality/aging / MGI
postnatal lethality, incomplete penetrance / MGI
increased circulating unsaturated transferrin level / MGI
decreased pancreas iron level / MGI
decreased heart iron level / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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C57BL/6N-Tmprss6tm1b(EUCOMM)Wtsi/Ics