C57BL/6N-Tmprss6tm1c(EUCOMM)Wtsi/Ics

Status

Available to order

EMMA IDEM:16229
Citation informationRRID:IMSR_EM:16229 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Tmprss6tm1c(EUCOMM)Wtsi/Ics
Alternative nameTmprss6tm1c(EUCOMM)Wtsi/Ics
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolTmprss6tm1c(EUCOMM)Wtsi
Gene/Transgene symbolTmprss6

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationWe used the EUCOMM ES clone EPD0453_1_B07 to to obtain mice carrying the Tmprss6tm1a(EUCOMM)Wtsi allele. The lacZ sequence and the NeoR cassette were removed through subsequent flp-mediated recombination, leaving a conditional-ready Tmprss6tm1c(EUCOMM)Wtsi allele with exon 3 (ENSMUSE00000230171; GRCm39, Tmprss6-201) floxed.
Phenotypic informationHomozygous:
N/A

Heterozygous:
N/A
Breeding history100% C57BL/6N (C57BL/6NCrl 93,65% C57BL/6NTac 6,35%)
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • short tibia / IMPC
  • decreased prepulse inhibition / IMPC
  • decreased mean corpuscular hemoglobin concentration / IMPC
  • abnormal coat/ hair morphology / IMPC
  • abnormal coat/hair pigmentation / IMPC
  • decreased exploration in new environment / IMPC
  • abnormal skin morphology / IMPC
  • decreased locomotor activity / IMPC
  • increased heart weight / IMPC
  • increased fasting circulating glucose level / IMPC
  • abnormal coat appearance / IMPC
  • increased Ly6C-positive mature NK cell number / IMPC
  • decreased NK cell number / IMPC
  • increased circulating calcium level / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • increased CD11b-high dendritic cell number / IMPC
  • decreased mean corpuscular volume / IMPC
  • decreased hemoglobin content / IMPC
  • increased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • immune system phenotype / IMPC
  • decreased CD8-positive, alpha-beta T cell number / IMPC
  • decreased hematocrit / IMPC
MGI phenotypes (gene matching)
  • decreased hematocrit / MGI
  • extramedullary hematopoiesis / MGI
  • abnormal hair follicle morphology / MGI
  • alopecia / MGI
  • sparse hair / MGI
  • focal hair loss / MGI
  • decreased body size / MGI
  • anemia / MGI
  • abnormal intestinal mineral absorption / MGI
  • postnatal growth retardation / MGI
  • abnormal iron level / MGI
  • reduced female fertility / MGI
  • female infertility / MGI
  • abnormal erythrocyte morphology / MGI
  • decreased mean corpuscular volume / MGI
  • reticulocytosis / MGI
  • anisopoikilocytosis / MGI
  • microcytic anemia / MGI
  • microcytosis / MGI
  • decreased hemoglobin content / MGI
  • decreased erythrocyte cell number / MGI
  • abnormal ovary development / MGI
  • pallor / MGI
  • maternal effect / MGI
  • decreased circulating iron level / MGI
  • increased spleen weight / MGI
  • hematopoietic system phenotype / MGI
  • decreased mean corpuscular hemoglobin / MGI
  • abnormal iron homeostasis / MGI
  • decreased mean corpuscular hemoglobin concentration / MGI
  • decreased liver iron level / MGI
  • decreased spleen iron level / MGI
  • progressive hair loss / MGI
  • increased red blood cell distribution width / MGI
  • abnormal hair follicle infundibulum morphology / MGI
  • thin hair follicle outer root sheath / MGI
  • mortality/aging / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • increased circulating unsaturated transferrin level / MGI
  • decreased pancreas iron level / MGI
  • decreased heart iron level / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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