Tmprss6tm1c(EUCOMM)Wtsi/Ics

Status	Available to order
EMMA ID	EM:16229
Citation information	RRID:IMSR_EM:16229 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	Tmprss6tm1c(EUCOMM)Wtsi/Ics
Alternative name	Tmprss6tm1c(EUCOMM)Wtsi/Ics
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Tmprss6tm1c(EUCOMM)Wtsi
Gene/Transgene symbol	Tmprss6

Information from provider

Provider	ICS, Institut Clinique de la Souris
Provider affiliation	ICS, Institut Clinique de la Souris
Genetic information	We used the EUCOMM ES clone EPD0453_1_B07 to to obtain mice carrying the Tmprss6tm1a(EUCOMM)Wtsi allele. The LacZ sequence and the NeoR cassette were removed through subsequent Flp-mediated recombination, leaving a conditional-ready allele with exon 3 (ENSMUSE00000230171) (GRCm39, Tmprss6-201) floxed.
Phenotypic information	Homozygous: N/A Heterozygous: N/A
Breeding history	100% C57BL/6N (C57BL/6NCrl 93,65% C57BL/6NTac 6,35%)
References	None available
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IRIDA syndrome / Orphanet_209981

IMPC phenotypes (gene matching)

short tibia / IMPC
decreased prepulse inhibition / IMPC
decreased mean corpuscular hemoglobin concentration / IMPC
abnormal coat/ hair morphology / IMPC
abnormal coat/hair pigmentation / IMPC
decreased exploration in new environment / IMPC
abnormal skin morphology / IMPC
decreased locomotor activity / IMPC
increased heart weight / IMPC
increased fasting circulating glucose level / IMPC
abnormal coat appearance / IMPC
increased Ly6C-positive mature NK cell number / IMPC
decreased NK cell number / IMPC
increased circulating calcium level / IMPC
decreased mean corpuscular hemoglobin / IMPC
increased CD11b-high dendritic cell number / IMPC
decreased mean corpuscular volume / IMPC
decreased hemoglobin content / IMPC
increased effector memory CD8-positive, alpha-beta T cell number / IMPC
immune system phenotype / IMPC
decreased CD8-positive, alpha-beta T cell number / IMPC
decreased hematocrit / IMPC

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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