C57BL/6N-Nrxn1tm1b(KOMP)Wtsi/H

Status

Only small colony available

EMMA IDEM:16263
Citation informationRRID:IMSR_EM:16263 

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International strain nameC57BL/6N-Nrxn1tm1b(KOMP)Wtsi/H
Alternative nameEPD0796_5_E08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolNrxn1tm1b(KOMP)Wtsi
Gene/Transgene symbolNrxn1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Mary Lyon Centre at MRC Harwell
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from KOMP ES clone EPD0796_5_E08. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele. Click here for more information on KOMP final vectors.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Pitt-Hopkins-like syndrome / Orphanet_221150
    • NRXN1-related severe neurodevelopmental disorder-motor stereotypies-chronic constipation-sleep-wake cycle disturbance / Orphanet_600663
IMPC phenotypes (allele matching)
  • decreased circulating HDL cholesterol level / IMPC
  • tremors / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • abnormal bone structure / IMPC
  • increased lean body mass / IMPC
  • decreased circulating cholesterol level / IMPC
  • impaired glucose tolerance / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • decreased circulating serum albumin level / IMPC
  • decreased circulating total protein level / IMPC
  • decreased pulmonary respiratory rate / IMPC
  • increased circulating amylase level / IMPC
  • decreased total body fat amount / IMPC
  • decreased grip strength / IMPC
  • decreased fasting circulating glucose level / IMPC
IMPC phenotypes (gene matching)
  • abnormal bone structure / IMPC
  • tremors / IMPC
  • increased circulating amylase level / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • decreased grip strength / IMPC
  • decreased pulmonary respiratory rate / IMPC
  • decreased circulating cholesterol level / IMPC
  • decreased total body fat amount / IMPC
  • decreased circulating total protein level / IMPC
  • decreased circulating serum albumin level / IMPC
  • impaired glucose tolerance / IMPC
  • decreased fasting circulating glucose level / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • increased lean body mass / IMPC
  • increased circulating aspartate transaminase level / IMPC
MGI phenotypes (gene matching)
  • increased grooming behavior / MGI
  • abnormal nest building behavior / MGI
  • no abnormal phenotype detected / MGI
  • abnormal motor learning / MGI
  • abnormal excitatory postsynaptic currents / MGI
  • abnormal nervous system physiology / MGI
  • decreased synaptic glutamate release / MGI
  • abnormal miniature excitatory postsynaptic currents / MGI
  • behavior/neurological phenotype / MGI
  • decreased prepulse inhibition / MGI

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Order (limited)

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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