C57BL/6N-Nbr1tm1b(KOMP)Wtsi/H

Status

Only small colony available

EMMA IDEM:16280
Citation informationRRID:IMSR_EM:16280 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Nbr1tm1b(KOMP)Wtsi/H
Alternative nameEPD0285_2_C09
Strain typeTargeted Mutant Strains
Allele/Transgene symbolNbr1tm1b(KOMP)Wtsi
Gene/Transgene symbolNbr1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Mary Lyon Centre at MRC Harwell
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from KOMP ES clone EPD0285_2_C09. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele (C57BL/6NTac-Tg(ACTB-cre)3Mrt/H). Click here for more information on KOMP final vectors.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)
  • impaired glucose tolerance / IMPC
IMPC phenotypes (gene matching)
  • impaired glucose tolerance / IMPC
MGI phenotypes (gene matching)
  • increased bone mineral density / MGI
  • abnormal osteoclast physiology / MGI
  • abnormal bone structure / MGI
  • increased bone mass / MGI
  • increased diameter of femur / MGI
  • increased diameter of humerus / MGI
  • abnormal osteoblast differentiation / MGI
  • abnormal bone trabecula morphology / MGI
  • increased bone trabecula number / MGI
  • increased trabecular bone volume / MGI
  • increased osteoid thickness / MGI
  • increased bone ossification / MGI

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Order (limited)

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
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