C57BL/6N-Alpk3tm1b(EUCOMM)Hmgu/H

Status

Only small colony available

EMMA IDEM:16281
Citation informationRRID:IMSR_EM:16281 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Alpk3tm1b(EUCOMM)Hmgu/H
Alternative nameHEPD0752_2_F08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAlpk3tm1b(EUCOMM)Hmgu
Gene/Transgene symbolAlpk3
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Mary Lyon Centre at MRC Harwell
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0752_2_F08. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele. Click here for more information on EUCOMM final vectors.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)
  • enlarged heart / IMPC
  • dilated heart left ventricle / IMPC
  • increased heart weight / IMPC
  • thick ventricular wall / IMPC
  • decreased cardiac muscle contractility / IMPC
  • increased heart left ventricle size / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
IMPC phenotypes (gene matching)
  • dilated heart left ventricle / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • decreased cardiac muscle contractility / IMPC
  • enlarged heart / IMPC
  • increased heart weight / IMPC
  • increased heart left ventricle size / IMPC
  • thick ventricular wall / IMPC
MGI phenotypes (gene matching)
  • enlarged heart / MGI
  • abnormal myocardial fiber morphology / MGI
  • cardiac hypertrophy / MGI
  • dilated heart left ventricle / MGI
  • increased heart weight / MGI
  • thick ventricular wall / MGI
  • decreased cardiac output / MGI
  • decreased cardiac muscle contractility / MGI
  • abnormal myocardium layer morphology / MGI
  • cardiomyopathy / MGI
  • decreased ventricle muscle contractility / MGI
  • decreased systemic arterial systolic blood pressure / MGI
  • abnormal intercalated disk morphology / MGI
  • abnormal heart layer morphology / MGI
  • myocardial hypertrophy / MGI
  • thick interventricular septum / MGI
  • abnormal heart left ventricle pressure / MGI
  • decreased cardiac stroke volume / MGI

Information on how we integrate external resources can be found here

Order (limited)

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.​
Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).